Summary

Overview
Global Cancer CDK Inhibitors Market reached US$ XX million in 2023 and is expected to reach US$ XX million by 2031, growing at a CAGR of XX% during the forecast period 2024-2031.
Cancer CDK (Cyclin-Dependent Kinase) inhibitors are a class of drugs designed to target and inhibit the activity of cyclin-dependent kinases, which are critical regulators of cell cycle progression. These inhibitors are primarily used in the treatment of various cancers, particularly those that exhibit dysregulated cell cycle control.
Market Dynamics: Drivers & Restraints
Increasing advancement in drug development
Advancements in drug development have shown the promising potential of CDK-4/6 inhibitors in breast cancer treatment. These inhibitors have been accepted in many countries due to their therapeutic efficacy compared to conventional treatments. The FDA has approved more inhibitory drug therapies, leading to the acceptance of new technologies in the field of breast cancer treatment. For example, GI Therapeutics began clinical trials for its CDK-4/6 inhibitor, trilaciclib, which is typically used in patients receiving gemcitabine and carboplatin for metastatic triple-negative breast cancer.

Side effects associated with cancer CDK inhibitors

CDK inhibitors are increasingly being used as a therapeutic option for breast and other cancers due to their unique side effects. The most common is neutropenia, a temporary, dose-dependent low white blood cell count that increases infection risk. Other side effects include leukopenia, anaemia, and thrombocytopenia.
However, diarrhea, fatigue, nausea, and alopecia are mild and reversible with regular breaks. These factors restrict market growth, making it crucial to understand their side effects and drug interactions as they become increasingly popular in treating cancers.

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Segment Analysis
The global cancer CDK inhibitors market is segmented based on drug type, cancer type, end-user, and region.
The palbiciclib from the drug type segment accounted for approximately 42.3% of the cancer CDK inhibitors market share
The palbiciclib from the drug type segment accounted for approximately 42.3%. Palbiciclib (Ibrance) can be used in combination with aromatase inhibitors to treat advanced-stage or metastatic, hormone receptor-positive, HER2-negative breast cancer that hasn't been treated with hormonal therapy before. Three aromatase inhibitors are Arimidex, Aromasin, and Femara. Ibrance can also be used in combination with Faslodex to treat advanced-stage or metastatic, hormone receptor-positive, HER2-negative breast cancer that has grown after hormonal therapy.
For instance, in January 2023, Dr Reddy's Laboratories acquired the trademark rights for the breast cancer drug PRIMCYV from Pfizer Products India for Indian market use. PRIMCYV is a targetted therapy containing palbociclib, a first-in-class CDK 4/6 inhibitor, used in combination with an aromatase inhibitor for first-line treatment of adult patients with HR+, HER2- metastatic breast cancer.
Geographical Analysis
North America is estimated to hold about 38.4% of the total market share throughout the forecast period
North America is estimated to hold about 38.4% of the total market share throughout the forecast period owing to factors like FDA approvals, and the rising prevalence of cancer in the U.S., which is the second-leading cause of death. Healthcare policies, high per capita spending, and advanced healthcare infrastructure.
For instance, in May 2024, Biotheryx, Inc., a biopharmaceutical company discovered and developed a portfolio of first-in-class protein degraders with a focus on validated targets in cancer and inflammatory disease, that the U.S. Food and Drug Administration (FDA) has cleared the Company's Investigational New Drug (IND) application for BTX-9341, a novel cyclin-dependent kinase 4/6 (CDK4/6) bifunctional degrader. The Company plans to initiate the Phase 1 clinical trial in the second half of 2024 and enroll patients with HR+/HER2- breast cancer resistant to CDK4/6 inhibitor therapies.
Market Segmentation
By Drug Type
• Palbiciclib
• Ribociclib
• Abemaciclib
• Others
By Cancer Type
• Breast Cancer
• Lung Cancer
• Prostate Cancer
• Colorectal Cancer
• Others
By Distribution channels
• Hospital Pharmacies
• Retail Pharmacies
• Online Pharmacies
By Region
• North America
o U.S.
o Canada
o Mexico
• Europe
o Germany
o UK
o France
o Italy
o Spain
o Rest of Europe
• South America
o Brazil
o Argentina
o Rest of South America
• Asia-Pacific
o China
o India
o Japan
o South Korea
o Rest of Asia-Pacific
• Middle East and Africa
Competitive Landscape
The major global players in the market include Pfizer Inc., Eli Lilly and Company, Novartis AG., Sanofi-Aventis, Merck & Co, Amgen, Bayer Pharmaceuticals, Piramal Life, G1 Therapeutics, AstraZeneca among others.
Key Developments
 In February 2024, Carrick Therapeutics dosed the first patient in its Phase 1b/2 clinical trial evaluating the combination of samuraciclib (CT7001), an oral CDK7 inhibitor, and vepdegestrant (ARV-471), an oral estrogen receptor degrader, jointly developed by Arvinas and Pfizer, in women with ER+, HER2- metastatic breast cancer who have previously received a CDK4/6 inhibitor.
 In November 2023, AstraZeneca's Truqap, a combination of Faslodex, has been approved in the US for treating adult breast cancer patients with hormone receptor-positive, HER2-negative, locally advanced or metastatic alterations. The FDA approved the treatment based on the results of the CAPItello-291 Phase III trial, which found Truqap in combination with Faslodex reduced the risk of disease progression or death by 50% compared to Faslodex alone in patients with PI3K/AKT pathway biomarker alterations.
Why Purchase the Report?
• To visualize the global cancer CDK inhibitors market segmentation based on drug type, cancer type, distribution channel, and region as well as understand key commercial assets and players.
• identify commercial opportunities by analyzing trends and co-development.
• excel data sheet with numerous data points of the cancer CDK inhibitors market level with all segments.
• PDF report consists of a comprehensive analysis after exhaustive qualitative interviews and an in-depth study.
• Product mapping available as Excel consisting of key products of all the major players.
The global cancer CDK inhibitors market report would provide approximately 64 tables, 61 figures, and 186 pages.
Target Audience 2023
• Manufacturers/ Buyers
• Industry Investors/Investment Bankers
• Research Professionals
• Emerging Companies

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Table of Contents

Table of Contents
1. Methodology and Scope
1.1. Research Methodology
1.2. Research Objective and Scope of the Report
2. Definition and Overview
3. Executive Summary
3.1. Snippet by Drug Type
3.2. Snippet by Cancer Type
3.3. Snippet by Distribution Channel
3.4. Snippet by Region
4. Dynamics
4.1. Impacting Factors
4.1.1. Drivers
4.1.1.1. Increasing advancement in drug development
4.1.1.2. Rise in the prevalence of cancer
4.1.2. Restraints
4.1.2.1. Side effects associated with cancer CDK inhibitors
4.1.2.2. XX
4.1.3. Opportunity
4.1.4. Impact Analysis
5. Industry Analysis
5.1. Porter's Five Force Analysis
5.2. Supply Chain Analysis
5.3. Pricing Analysis
5.4. Regulatory Analysis
5.5. Patent Analysis
5.6. PESTLE Analysis
5.7. SWOT Analysis
5.8. DMI Opinion
6. COVID-19 Analysis
6.1. Analysis of COVID-19
6.1.1. Scenario Before COVID
6.1.2. Scenario During COVID
6.1.3. Scenario Post COVID
6.2. Pricing Dynamics Amid COVID-19
6.3. Demand-Supply Spectrum
6.4. Government Initiatives Related to the Market During Pandemic
6.5. Manufacturers Strategic Initiatives
6.6. Conclusion
7. By Drug Type
7.1. Introduction
7.1.1. Market Size Analysis and Y-o-Y Growth Analysis (%), By Drug Type
7.1.2. Market Attractiveness Index, By Drug Type
7.2. Palbiciclib*
7.2.1. Introduction
7.2.2. Market Size Analysis and Y-o-Y Growth Analysis (%)
7.3. Ribociclib
7.4. Abemaciclib
7.5. Others
8. By Cancer Type
8.1. Introduction
8.1.1. Market Size Analysis and Y-o-Y Growth Analysis (%), By Cancer Type
8.2. Market Attractiveness Index, By Cancer Type
8.3. Breast Cancer*
8.3.1. Introduction
8.3.2. Market Size Analysis and Y-o-Y Growth Analysis (%)
8.4. Lung Cancer
8.5. Prostate Cancer
8.6. Colorectal Cancer
8.7. Others
9. By Distribution Channel
9.1. Introduction
9.1.1. Market Size Analysis and Y-o-Y Growth Analysis (%), By Distribution Channel
9.1.2. Market Attractiveness Index, By Distribution Channel
9.2. Hospital Pharmacies*
9.2.1. Introduction
9.2.2. Market Size Analysis and Y-o-Y Growth Analysis (%)
9.3. Retail Pharmacies
9.4. Online Pharmacies
10. By Region
10.1. Introduction
10.1.1. Market Size Analysis and Y-o-Y Growth Analysis (%), By Region
10.1.2. Market Attractiveness Index, By Region
10.2. North America
10.2.1. Introduction
10.2.2. Key Region-Specific Dynamics
10.2.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Drug Type
10.2.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Cancer Type
10.2.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By Distribution Channel
10.2.6. Market Size Analysis and Y-o-Y Growth Analysis (%), By Country
10.2.6.1. U.S.
10.2.6.2. Canada
10.2.6.3. Mexico
10.3. Europe
10.3.1. Introduction
10.3.2. Key Region-Specific Dynamics
10.3.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Drug Type
10.3.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Cancer Type
10.3.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By Distribution Channel
10.3.6. Market Size Analysis and Y-o-Y Growth Analysis (%), By Country
10.3.6.1. Germany
10.3.6.2. UK
10.3.6.3. France
10.3.6.4. Italy
10.3.6.5. Spain
10.3.6.6. Rest of Europe
10.4. South America
10.4.1. Introduction
10.4.2. Key Region-Specific Dynamics
10.4.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Drug Type
10.4.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Cancer Type
10.4.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By Distribution Channel
10.4.6. Market Size Analysis and Y-o-Y Growth Analysis (%), By Country
10.4.6.1. Brazil
10.4.6.2. Argentina
10.4.6.3. Rest of South America
10.5. Asia-Pacific
10.5.1. Introduction
10.5.2. Key Region-Specific Dynamics
10.5.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Drug Type
10.5.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Cancer Type
10.5.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By Distribution Channel
10.5.6. Market Size Analysis and Y-o-Y Growth Analysis (%), By Country
10.5.6.1. China
10.5.6.2. India
10.5.6.3. Japan
10.5.6.4. South Korea
10.5.6.5. Rest of Asia-Pacific
10.6. Middle East and Africa
10.6.1. Introduction
10.6.2. Key Region-Specific Dynamics
10.6.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Drug Type
10.6.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Cancer Type
10.6.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By Distribution Channel
11. Competitive Landscape
11.1. Competitive Scenario
11.2. Market Positioning/Share Analysis
11.3. Mergers and Acquisitions Analysis
12. Company Profiles
12.1. Pfizer Inc*
12.1.1. Company Overview
12.1.2. Product Portfolio and Description
12.1.3. Financial Overview
12.1.4. Key Developments
12.2. Eli Lilly and Company
12.3. Novartis AG.
12.4. Sanofi-Aventis
12.5. Merck & Co
12.6. Amgen
12.7. Bayer Pharmaceuticals
12.8. Piramal Life
12.9. G1 Therapeutics
12.10. AstraZeneca
LIST NOT EXHAUSTIVE
13. Appendix
13.1. About Us and Services
13.2. Contact Us