Summary

Overview
Global uveal melanoma treatment market reached US$ XX million in 2022 and is expected to reach US$ XX million by 2030, growing at a CAGR of XX% during the forecast period 2023-2030.
Uveal melanoma is a rare type of cancer that occurs in the tissues of the eye. Also called intraocular or ocular melanoma, this type of cancer occurs in only 5 people per million. However, it can resist treatment and spread quickly through the body. This malignant neoplasia is composed of atypical melanocytes. Melanocytes are cells that are normally found in the iris, ciliary body and choroid. A proliferation of atypical melanocytes that appear in any of these three structures forms an uveal melanoma. However, depending on its location and structure, each tumor has some particularities.
Choroidal melanoma is the most common subtype of uveal melanoma. Melanoma of the ciliary body is rarely seen. The anatomical location seems to be the key outcome. Surgical excision of the tumor, also known as iridectomy or iridocyclectomy, can be used for small, circumscribed iris and ciliary body melanomas with the removal of part of the iris as well as the adjacent ciliary body. The main treatment options for iris, ciliary body and choroid melanoma include radioactive plaque therapy and enucleation. A new type of Immunotherapy called, Tebentafusp (Kimmtrak) and HEPZATO KIT (Chemotherapy (melphalan hydrochloride) for injection/hepatic delivery system) was approved by the FDA to treat uveal melanoma.
Market Dynamics: Drivers
A surge in adoption of advanced cancer drug therapies
The surge in adoption of advanced cancer drug therapies is expected to drive the market over the forecast period. Advanced cancer drug therapies aim to address the unmet needs associated with uveal melanoma by providing better treatment. Some advanced cancer drug therapies have demonstrated improved efficacy and survival benefits. Immunotherapies, in particular, can harness the body's immune system to target and destroy cancer cells, leading to durable responses in some patients.
Advances in genomics and molecular biology have allowed for a better understanding of the genetic and molecular characteristics of individual tumors. This has paved the way for personalized medicine, where treatments are tailored to the specific genetic makeup of a patient's cancer. Targeted therapies are designed to interfere with specific molecules involved in cancer growth and progression. The chemotherapy (melphalan hydrochloride) for injection/hepatic delivery system (HEPZATO KIT) is an advanced therapy which was approved by the FDA.
For instance, on August 14, 2023, Delcath Systems, Inc., an interventional oncology company focused on the treatment of primary and metastatic cancers of the liver, cleared that the US Food and Drug Administration (FDA) approved HEPZATO KIT (melphalan/Hepatic Delivery System) as a liver-directed treatment for adult patients with metastatic uveal melanoma (mUM) with unresectable hepatic metastases affecting less than 50% of the liver and no extrahepatic disease, or extrahepatic disease limited to the bone, lymph nodes, subcutaneous tissues or lung that is amenable to resection or radiation.
Pharmaceutical companies and research institutions continue to invest heavily in the development of novel cancer therapies. This commitment to research and development has led to the discovery of new treatment modalities and innovative approaches. These increasing investments helps to increase the clinical trials to develop advanced cancer therapies to treat uveal melanoma.
For instance, in October 2023, iOnctura was granted an investigational new drug application for roginolisib by the FDA, with plans to launch a new Phase I trial. The FDA has granted its approval for the Swiss company to carry out clinical investigations into Roginolisib (IOA-244) as part of its investigational new drug (IND) application, which is aimed at treating conditions such as solid and haematologic malignancies, including uveal melanoma.
Further, the increasing prevalence of uveal melanoma, rising FDA approvals, increasing clinical trials and increasing awareness about uveal melanoma and their treatment options are the factors expected to drive the market over the forecast period.
Restraints
Factors such as complications associated with the various treatment therapies and surgery, the high cost of the uveal melanoma surgery and side effects associated with various therapeutics are the factors expected to hamper the market.
Segment Analysis
The global uveal melanoma treatment market is segmented based on disease type, treatment, end-user and region.
The immunotherapy segment accounted for approximately 59.6% of the uveal melanoma treatment market share
The immunotherapy segment is expected to hold the largest market share over the forecast period. Immunotherapy is a treatment that works by encouraging the immune system to attack cancer cells. The immunotherapy drug, tebentafusp is a type of treatment called a bispecific fusion protein. It works by helping immune cells get close enough to cancer cells to attack them. The clinical trial evaluated the drug as an initial treatment for people with metastatic uveal melanoma. The tebentafusp was approved by the FDA for the treatment of uveal melanoma.
For instance, on January 26, 2022, Immunocore Holdings plc, a commercial-stage biotechnology company pioneering the development of a novel class of T cell receptor (TCR) bispecific immunotherapies designed to treat a broad range of diseases, including cancer, autoimmune and infectious diseases cleared the approval from the United States Food and Drug Administration (FDA) for KIMMTRAK (tebentafusp-tebn) for the treatment of HLA-A*02:01-positive adult patients with unresectable or metastatic uveal melanoma.
Tebentafusp is engineered to target a protein called gp100, which is expressed on the surface of uveal melanoma cells. By binding to gp100, Tebentafusp activates T cells, directing them to attack and kill the cancer cells. The drug promotes the activation of T cells, a critical component of the immune system. Activated T cells play a key role in recognizing and destroying cancer cells. Clinical trials have demonstrated encouraging results for Tebentafusp in treating metastatic uveal melanoma. The drug has shown effectiveness in improving overall survival compared to other treatments.
Geographical Analysis
North America accounted for approximately 42.6% of the market share
North America region is expected to hold the largest market share over the forecast period owing to the strong presence of major players and increasing research activities. North America especially the United States is known for its strong presence of major players such as pharmaceutical and medical device companies, which actively focus on the development of more advanced therapies to treat uveal melanoma.
Furthermore, increasing research activities also helps to develop more advanced therapeutics for the better management of the symptoms in the early stages. As the research activities increase, the therapeutics are developed more precisely by reducing the adverse effects and complications associated with the therapeutics, which results in better patient outcomes. There is an increasing number of clinical trials to develop more advanced treatment options for patients.
For instance, on June 6, 2023, Linnaeus Therapeutics, Inc. released the presentation of clinical data from its phase 1 dose-expansion study of LNS8801 as a monotherapy and in combination with pembrolizumab in metastatic uveal melanoma. LNS8801 alone and in combination with pembrolizumab was tolerable without unanticipated toxicities. LNS8801 demonstrated encouraging anti-tumor activity in patients with metastatic uveal melanoma, overall 50% of patients had disease control. These data support further development of LNS8801 alone and in combination with pembrolizumab as a therapeutic approach to treat metastatic uveal melanoma patients.
Competitive Landscape
The major global players in the uveal melanoma treatment market include Delcath Systems, Inc., Immunocore, Ltd., Eli Lilly and Company, iOnctura SA, Linnaeus Therapeutics, Inc., AstraZeneca Plc., IDEAYA Biosciences, Inc., Verastem, Inc., Foghorn Therapeutics and InxMed among others.
COVID-19 Impact Analysis
The COVID-19 pandemic significantly impacted the global uveal melanoma treatment market. The pandemic created unprecedented challenges for pharmaceutical industries worldwide, including the global uveal melanoma treatment market by temporarily disrupting many clinical trials and research activities due to the redirected focus on the COVID-19 pandemic and its related restrictions, the pandemic also postponed the surgeries. The COVID-19 pandemic also disrupted the supply chain of these treatment drugs and devices globally.
Market Segmentation
By Disease Type
• Choroid Melanoma
• Iris Melanoma
• Ciliary Melanoma
By Treatment
• Ruthenium Plaque Brachytherapy
• Proton Beam Radiotherapy
• Photodynamic Therapy
• Thermotherapy (Heat Therapy)
• Surgery
o Local Resection
o Iridectomy
o Enucleation
o Exenteration
o Eye Reconstructive Surgery
• Immunotherapy (Tebentafusp)
• Others
By End-User
• Hospitals
• Specialty Clinics
• Radiotherapy Centers
• Ambulatory Surgical Centers
• Others
By Region
• North America
o U.S.
o Canada
o Mexico
• Europe
o Germany
o U.K.
o France
o Spain
o Italy
o Rest of Europe
• South America
o Brazil
o Argentina
o Rest of South America
• Asia-Pacific
o China
o India
o Japan
o Australia
o Rest of Asia-Pacific
• Middle East and Africa
Why Purchase the Report?
• To visualize the global uveal melanoma treatment market segmentation based on disease type, treatment, end-user and region as well as understand key commercial assets and players.
• Identify commercial opportunities by analyzing trends and co-development
• Excel data sheet with numerous data points of uveal melanoma treatment market-level with all segments.
• PDF report consists of a comprehensive analysis after exhaustive qualitative interviews and an in-depth study.
• Product mapping available as excel consisting of key products of all the major players.
The global uveal melanoma treatment market report would provide approximately 61 tables, 63 figures, and 187 Pages.
Target Audience 2023
• Manufacturers/ Buyers
• Industry Investors/Investment Bankers
• Research Professionals
• Emerging Companies

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Table of Contents

1. Methodology and Scope
1.1. Research Methodology
1.2. Research Objective and Scope of the Report
2. Definition and Overview
3. Executive Summary
3.1. Snippet by Disease Type
3.2. Snippet by Treatment
3.3. Snippet by End-User
3.4. Snippet by Region
4. Dynamics
4.1. Impacting Factors
4.1.1. Drivers
4.1.1.1. A Surge in Adoption of Advanced Cancer Drug Therapies
4.1.2. Restraints
4.1.2.1. Complications Associated with the Surgery
4.1.3. Opportunity
4.1.4. Impact Analysis
5. Industry Analysis
5.1. Porter's Five Force Analysis
5.2. Supply Chain Analysis
5.3. Pricing Analysis
5.4. Regulatory Analysis
5.5. Pipeline Analysis
5.6. Unmet Needs
5.7. Patent Analysis
5.8. SWOT Analysis
5.9. PESTEL Analysis
6. COVID-19 Analysis
6.1. Analysis of COVID-19
6.1.1. Scenario Before COVID
6.1.2. Scenario During COVID
6.1.3. Scenario Post COVID
6.2. Pricing Dynamics Amid COVID-19
6.3. Demand-Supply Spectrum
6.4. Government Initiatives Related to the Market During the Pandemic
6.5. Manufacturers Strategic Initiatives
6.6. Conclusion
7. By Disease Type
7.1. Introduction
7.1.1. Market Size Analysis and Y-o-Y Growth Analysis (%), By Disease Type
7.1.2. Market Attractiveness Index, By Disease Type
7.2. Choroid Melanoma*
7.2.1. Introduction
7.2.2. Market Size Analysis and Y-o-Y Growth Analysis (%)
7.3. Iris Melanoma
7.4. Ciliary Melanoma
8. By Treatment
8.1. Introduction
8.1.1. Market Size Analysis and Y-o-Y Growth Analysis (%), By Treatment
8.1.2. Market Attractiveness Index, By Treatment
8.2. Ruthenium Plaque Brachytherapy*
8.2.1. Introduction
8.2.2. Market Size Analysis and Y-o-Y Growth Analysis (%)
8.3. Proton Beam Radiotherapy
8.4. Photodynamic Therapy
8.5. Thermotherapy (Heat Therapy)
8.6. Surgery
8.6.1. Local Resection
8.6.2. Iridectomy
8.6.3. Enucleation
8.6.4. Exenteration
8.7. Immunotherapy (Tebentafusp)
8.8. Others
9. By End-User
9.1. Introduction
9.1.1. Market Size Analysis and Y-o-Y Growth Analysis (%), By End-User
9.1.2. Market Attractiveness Index, By End-User
9.2. Hospitals*
9.2.1. Introduction
9.2.2. Market Size Analysis and Y-o-Y Growth Analysis (%)
9.3. Hospitals
9.4. Specialty Clinics
9.5. Radiotherapy Centers
9.6. Ambulatory Surgical Centers
9.7. Others
10. By Region
10.1. Introduction
10.1.1. Market Size Analysis and Y-o-Y Growth Analysis (%), By Region
10.1.2. Market Attractiveness Index, By Region
10.2. North America
10.2.1. Introduction
10.2.2. Key Region-Specific Dynamics
10.2.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Disease Type
10.2.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Treatment
10.2.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By End-User
10.2.6. Market Size Analysis and Y-o-Y Growth Analysis (%), By Country
10.2.6.1. U.S.
10.2.6.2. Canada
10.2.6.3. Mexico
10.3. Europe
10.3.1. Introduction
10.3.2. Key Region-Specific Dynamics
10.3.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Disease Type
10.3.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Treatment
10.3.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By End-User
10.3.6. Market Size Analysis and Y-o-Y Growth Analysis (%), By Country
10.3.6.1. Germany
10.3.6.2. UK
10.3.6.3. France
10.3.6.4. Italy
10.3.6.5. Spain
10.3.6.6. Rest of Europe
10.4. South America
10.4.1. Introduction
10.4.2. Key Region-Specific Dynamics
10.4.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Disease Type
10.4.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Treatment
10.4.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By End-User
10.4.6. Market Size Analysis and Y-o-Y Growth Analysis (%), By Country
10.4.6.1. Brazil
10.4.6.2. Argentina
10.4.6.3. Rest of South America
10.5. Asia-Pacific
10.5.1. Introduction
10.5.2. Key Region-Specific Dynamics
10.5.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Disease Type
10.5.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Treatment
10.5.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By End-User
10.5.6. Market Size Analysis and Y-o-Y Growth Analysis (%), By Country
10.5.6.1. China
10.5.6.2. India
10.5.6.3. Japan
10.5.6.4. Australia
10.5.6.5. Rest of Asia-Pacific
10.6. Middle East and Africa
10.6.1. Introduction
10.6.2. Key Region-Specific Dynamics
10.6.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Disease Type
10.6.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Treatment
10.6.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By End-User
11. Competitive Landscape
11.1. Competitive Scenario
11.2. Market Positioning/Share Analysis
11.3. Mergers and Acquisitions Analysis
12. Company Profiles
12.1. Delcath Systems, Inc.*
12.1.1. Company Overview
12.1.2. Product Portfolio and Description
12.1.3. Financial Overview
12.1.4. Key Developments
12.2. Immunocore, Ltd.
12.3. Eli Lilly and Company
12.4. iOnctura SA
12.5. Linnaeus Therapeutics, Inc.
12.6. AstraZeneca Plc.
12.7. IDEAYA Biosciences, Inc.
12.8. Verastem, Inc.
12.9. Foghorn Therapeutics
12.10. InxMed
LIST NOT EXHAUSTIVE
13. Appendix
13.1. About Us and Services
13.2. Contact Us