Summary

Overview
Global Acute on Chronic Liver Failure market reached US$ XX million in 2023 and is expected to reach US$ XX million by 2031, growing at a CAGR of XX% during the forecast period 2024-2031.
Acute-on-Chronic Liver Failure (ACLF) is a critical medical condition characterised by the sudden deterioration of liver function in individuals with underlying chronic liver disease. This complex syndrome is marked by a rapid onset of severe liver dysfunction and is often associated with multiple organ failures. ACLF requires immediate medical attention and intervention, posing a high mortality risk. Effective management strategies and early detection are crucial in improving the prognosis for patients with ACLF, making it a significant focus in gastroenterology and hepatology.
Market Dynamics: Drivers & Restraints
Rise in the prevalence of chronic liver diseases
The rise in chronic liver diseases like cirrhosis and hepatitis is a significant factor contributing to the development of acute on chronic liver failure (ACLF). For instance, Liver disease accounts for two million deaths annually and is responsible for 4% of all deaths (1 out of every 25 deaths worldwide); approximately two-thirds of all liver-related deaths occur in men. Within this estimate, liver cancer accounts for 600,000 to 900,000 deaths per year.
Currently, liver disease is the eleventh-leading cause of death, but liver deaths may be underestimated. Deaths are largely attributable to complications of cirrhosis and hepatocellular carcinoma, with acute hepatitis accounting for a smaller proportion of deaths.
Furthermore, the global acute on chronic liver failure market is also driven by various factors like high-risk patient populations, government initiatives to promote awareness and others that help the market to grow during the forecast period.
Complications associated with the disease
The complications associated with acute or chronic liver failure (ACLF) include multisystem organ failure and poor prognosis in hospitalized patients with cirrhosis. ACLF is characterized by rapid clinical deterioration and is associated with high short-term morbidity, mortality, and healthcare resource utilization. Also, complications like infections, kidney problems and other issues will also occur after liver transplantation.
Segment Analysis
The global acute on chronic liver failure market is segmented based on disease type, therapy type, end user and region.
The liver transplantation from the therapy type segment accounted for approximately 47.1% of the acute on chronic liver failure market share
The liver transplantation from the therapy type segment accounted for approximately 47.1% Acute-on-chronic liver failure (ACLF) is a syndrome that develops in 30% of the patients hospitalized due to cirrhosis. About 30% of patients with ACLF will die within 28 days of hospital admission. Although liver transplantation has been shown to be the most effective treatment for patients with ACLF grade 2-3 to date, with more than an 80% survival rate after 1 year of receiving a liver transplant access to liver transplantation in some European countries is limited in treating patients with cirrhosis. In collaboration with the European Liver and Intestine Transplantation Society (ELITA) and the International Liver Transplantation Society (ILTS), EF Clif launched the CHANCE study, its largest prospective non-interventional observational global study to assess the survival rate of patients with cirrhosis who receive a liver transplant.
Geographical Analysis
North America is Expected to Dominate the Global Market
North America is estimated to hold about 38.4% of the total market share throughout the forecast period owing to the factors increasing awareness, and rising incidence of liver failure in the region. Additionally, due to the growing ageing population and increasing awareness regarding the available treatment options for the population also help the region to have the highest market share.
For instance, in May 2023, Seal Rock Therapeutics, Inc., a clinical-stage company developing first-in-class and best-in-class kinase inhibitors, stated that it has entered into an out-licensing agreement with GENFIT for the development of an injectable formulation of SRT-015 for acute liver disease, including Acute-on-Chronic Liver Failure (ACLF).
Covid 19 Impact Analysis
COVID-19 significantly impacts patients with compensated chronic liver disease (CLD), increasing the risk of disease progression and acute-on-chronic liver failure (ACLF). CLD patients have a higher risk of severe or critical COVID-19 and higher mortality, while ACLF is observed in some patients with pre-existing compensated CLD who had severe COVID-19. Furthermore, patients with CLD are more likely to experience severe or critical COVID-19 and higher mortality.
Market Segmentation
By Disease Type
• Type-A ACLF
• Type B ACLF
• Type C ACLF
By Therapy Type
• Liver Transplantation
• Supportive Care
• Medications
• Others
By End User
• Hospitals
• Ambulatory Surgical Centers
• Others
By Region
• North America
o U.S.
o Canada
o Mexico
• Europe
o Germany
o UK
o France
o Italy
o Spain
o Rest of Europe
• South America
o Brazil
o Argentina
o Rest of South America
• Asia-Pacific
o China
o India
o Japan
o Australia
o Rest of Asia-Pacific
• Middle East and Africa
Key Developments
 In June 2023, Ipsen and GENFIT stated that positive topline data from the pivotal ELATIVE Phase III trial. In the trial the efficacy and safety of elafibranor, an investigational dual α,δ PPAR agonist, is being assessed for the treatment of patients with the rare cholestatic liver disease, primary biliary cholangitis (PBC), who have an inadequate response or intolerance to the current standard of care therapy, ursodeoxycholic acid (UDCA).
Competitive Landscape
The major global players in the market include Grifols Therapeutics, Genefit (Versantis), Martin Pharmaceuticals, Fresenius SE & Co. KGaA, Cellaion, Yaqrit Discovery Ltd, GNI Group Ltd among others.
Why Purchase the Report?
• To visualize the global acute on chronic liver failure market segmentation based on disease type, therapy type, end user and region as well as understand key commercial assets and players.
• Identify commercial opportunities by analysing trends and co-development.
• Excel data sheet with numerous data points of acute on chronic liver failure market-level with all segments.
• PDF report consists of a comprehensive analysis after exhaustive qualitative interviews and an in-depth study.
• Product mapping available as excel consisting of key products of all the major players.
The global acute on chronic liver failure market report would provide approximately 64 tables, 61 figures and 186 pages.
Target Audience 2023
• Manufacturers/ Buyers
• Industry Investors/Investment Bankers
• Research Professionals
• Emerging Companies

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Table of Contents

1. Methodology and Scope
1.1. Research Methodology
1.2. Research Objective and Scope of the Report
2. Definition and Overview
3. Executive Summary
3.1. Snippet by Disease Type
3.2. Snippet by Therapy Type
3.3. Snippet by End User
3.4. Snippet by Region
4. Dynamics
4.1. Impacting Factors
4.1.1. Drivers
4.1.1.1. Rise in the prevalence of chronic liver diseases
4.1.1.2. Government initiatives to promote awareness
4.1.2. Restraints
4.1.2.1. Complications associated with the treatment
4.1.2.2. XX
4.1.3. Opportunity
4.1.4. Impact Analysis
5. Industry Analysis
5.1. Porter's Five Force Analysis
5.2. Supply Chain Analysis
5.3. Pricing Analysis
5.4. Regulatory Analysis
5.5. Patent Analysis
5.6. Pipeline Analysis
5.7. Epidemiology
5.8. SWOT Analysis
5.9. DMI Opinion
6. COVID-19 Analysis
6.1. Analysis of COVID-19
6.1.1. Scenario Before COVID
6.1.2. Scenario During COVID
6.1.3. Scenario Post COVID
6.2. Pricing Dynamics Amid COVID-19
6.3. Demand-Supply Spectrum
6.4. Government Initiatives Related to the Market During Pandemic
6.5. Manufacturers Strategic Initiatives
6.6. Conclusion
7. By Disease Type
7.1. Introduction
7.1.1. Market Size Analysis and Y-o-Y Growth Analysis (%), By Disease Type
7.1.2. Market Attractiveness Index, By Disease Type
7.2. Type-A ACLF*
7.2.1. Introduction
7.2.2. Market Size Analysis and Y-o-Y Growth Analysis (%)
7.3. Type B ACLF
7.4. Type C ACLF
8. By Therapy Type
8.1.1. Market Size Analysis and Y-o-Y Growth Analysis (%), By Route of Administration
8.1.2. Market Attractiveness Index, By Route of Administration
8.2. Liver Transplantation *
8.2.1. Introduction
8.2.2. Market Size Analysis and Y-o-Y Growth Analysis (%)
8.3. Supportive Care
8.4. Medications
8.5. Others
9. By End User
9.1. Introduction
9.1.1. Market Size Analysis and Y-o-Y Growth Analysis (%), By End User
9.1.2. Market Attractiveness Index, By End User
9.2. Hospitals*
9.2.1. Introduction
9.2.2. Market Size Analysis and Y-o-Y Growth Analysis (%)
9.3. Ambulatory Surgical Centers
9.4. Others
10. By Region
10.1. Introduction
10.1.1. Market Size Analysis and Y-o-Y Growth Analysis (%), By Region
10.1.2. Market Attractiveness Index, By Region
10.2. North America
10.2.1. Introduction
10.2.2. Key Region-Specific Dynamics
10.2.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Disease Type
10.2.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Therapy Type
10.2.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By End User
10.2.6. Market Size Analysis and Y-o-Y Growth Analysis (%), By Country
10.2.6.1. U.S.
10.2.6.2. Canada
10.2.6.3. Mexico
10.3. Europe
10.3.1. Introduction
10.3.2. Key Region-Specific Dynamics
10.3.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Disease Type
10.3.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Therapy Type
10.3.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By End User
10.3.6. Market Size Analysis and Y-o-Y Growth Analysis (%), By Country
10.3.6.1. Germany
10.3.6.2. UK
10.3.6.3. France
10.3.6.4. Italy
10.3.6.5. Spain
10.3.6.6. Rest of Europe
10.4. South America
10.4.1. Introduction
10.4.2. Key Region-Specific Dynamics
10.4.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Disease Type
10.4.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Therapy Type
10.4.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By End User
10.4.6. Market Size Analysis and Y-o-Y Growth Analysis (%), By Country
10.4.6.1. Brazil
10.4.6.2. Argentina
10.4.6.3. Rest of South America
10.5. Asia-Pacific
10.5.1. Introduction
10.5.2. Key Region-Specific Dynamics
10.5.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Disease Type
10.5.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Therapy Type
10.5.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By End User
10.5.6. Market Size Analysis and Y-o-Y Growth Analysis (%), By Country
10.5.6.1. China
10.5.6.2. India
10.5.6.3. Japan
10.5.6.4. Australia
10.5.6.5. Rest of Asia-Pacific
10.6. Middle East and Africa
10.6.1. Introduction
10.6.2. Key Region-Specific Dynamics
10.6.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Disease Type
10.6.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Therapy Type
10.6.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By End User
11. Competitive Landscape
11.1. Competitive Scenario
11.2. Market Positioning/Share Analysis
11.3. Mergers and Acquisitions Analysis
12. Company Profiles
12.1. Grifols Therapeutics*
12.1.1. Company Overview
12.1.2. Product Portfolio and Description
12.1.3. Financial Overview
12.1.4. Key Developments
12.2. Genefit (Versantis)
12.3. Martin Pharmaceuticals
12.4. Fresenius SE & Co. KGaA
12.5. Cellaion
12.6. Yaqrit Discovery Ltd
12.7. GNI Group Ltd
LIST NOT EXHAUSTIVE
13. Appendix
13.1. About Us and Services
13.2. Contact Us