Summary

Overview
Global protein purification & isolation market reached US$ XX million in 2022 and is expected to reach US$ XX million by 2030, growing at a CAGR of XX% during the forecast period 2023-2030.
Protein purification is the method of separating a target protein from the other cellular components and contaminants resulting in a sample predominantly composed of the protein. The most common methods include chromatography, electrophoresis, precipitation and filtration. Protein isolation is the process of extracting a protein from its natural sources, such as cells, tissues or biological fluids. It involves breaking down complex biological material to release the protein of interest and purifying it, involving steps like cell lysis, extraction and purification.
The process involves disrupting cells or tissues to release cellular components, including the target protein. The soluble fraction is separated from insoluble components and various techniques are used to isolate the protein from other components. The identity, purity and functionality of the isolated protein are confirmed using analytical methods. Protein purification and isolation are critical in various fields, including biochemistry, molecular biology, biotechnology and pharmaceuticals, where pure proteins are essential for studying their structure, function and interactions, as well as for developing therapeutic drugs and diagnostic tools.
Market Dynamics: Drivers
Increasing demand for accurate and rapid purification technologies
The increasing demand for accurate and rapid purification technologies is expected to drive the market over the forecast period. The focus is on enhancing efficiency and productivity in research and industrial settings through the use of accurate and rapid purification technologies. The biopharmaceutical industry, which heavily relies on purified proteins for therapeutic purposes, is expanding rapidly, necessitating efficient purification technologies to ensure high yields and product quality in the protein production process.
For instance, on November 17, 2023, Cytiva launched the revolutionary Cytiva Protein Select technology, aimed at streamlining and expediting the process of recombinant protein purification. This innovative technology introduces a self-cleaving traceless tag and a complementary affinity chromatography resin, revolutionizing the standardization of protein purification. It eliminates the need for specific affinity binding partners tailored to each protein, presenting a universal approach to purification.
In addition, researchers in drug discovery need rapid and accurate protein purification methods to identify and characterize potential drug candidates, accelerating the drug development pipeline by isolating specific proteins for further analysis. High-throughput screening in proteomics and personalized medicine requires purification technologies that can efficiently process large samples without compromising accuracy.
For instance, on June 2, 2022, Navigo Proteins GmbH released the successful development of an affinity resin to capture an undesired contaminant from the baculovirus insect cell expression system, namely the glycoprotein gp64. Navigo successfully leveraged the Precision Capturing technology to develop a Precision X ligand binding to the gp64 contaminant. The innovative resin will be used in a flow-through chromatography mode, where the envelope protein is bound to the resin and the recombinant protein of interest is eluted without interaction, thereby removing the contaminant protein from the production train.
Further, the increasing adoption in drug discovery and development, increasing awareness, increasing investments, increasing demand for protein purification kits in biotechnology companies and increasing technological advancements are the factors that are expected to drive the market over the forecast period.
Restraints
Factors such as complications associated with the protein purification instruments and consumables and the high cost associated with the protein purification and isolation kits are expected to hamper the market.
Segment Analysis
The global protein purification & isolation market is segmented based on product type, technology, end-user and region.
The consumables segment accounted for approximately 38.2% of the protein purification & isolation market share
The consumables segment is expected to hold the largest market share over the forecast period. The protein purification consumables like kits, reagents and columns simplify the purification process by benefiting researchers and technicians with varying expertise levels. Prepackaged consumables save researchers time by eliminating the need to prepare solutions or media from scratch, thereby enhancing the efficiency of experimental setup and execution.
For instance, on August 17, 2022, Bio-Rad Laboratories, Inc. launched EconoFit Low-Pressure Prepacked Chromatography Column Packs to support resin screening experiments in the development of protein purification workflows. Bio-Rad’s range of EconoFit Columns provides a wide selection of resins in a prepacked format. The new packs include mixed-mode, cation, and anion exchange resin columns, as well as a pack designed for His-tag protein purification.
Standardized kits and other consumables ensure consistency and reproducibility across experiments and users, ensuring reliable and comparable results in scientific research and bioprocessing. Prepackaged consumables, manufactured in controlled environments, reduce contamination risk by preventing impurities from entering the purification process. Kits and other consumables, despite their higher upfront cost, often prove cost-effective due to time saved, increased efficiency and reduced error risk.
For instance, on March 10, 2022, Opentrons Robotics launched four new OT-2 workstation products supporting popular applications, including NGS, PCR and protein purification. Dual Flow Chromatography-Based Protein Purification Workstation, enabling automated protein purification with Biotage PhyTip columns to maximize binding interactions and sample recovery. Magnetic Bead-Based Protein Purification and Protein Assay Workstation, enabling automated protein purification and sample preparation for proteomics.
Geographical Analysis
North America accounted for approximately 41.2% of the market share
North America region is expected to hold the largest market share over the forecast period owing to the strong presence of major players and increasing investments to develop the biotechnology industry in the region. North America especially the United States is known for its strong presence of major players such as biotechnology companies and pharmaceutical companies. The presence of major players actively focuses on developing more advanced and accurate purification equipments and consumables.
For instance, on March 20, 2020, Avantor, Inc., a leading global provider of mission-critical products and services to customers in the life sciences, advanced technologies and applied materials industries, launched a new recombinant Protein A affinity chromatography resin used to purify antibodies during mAbs production.
North America, particularly the United States and Canada is a leading player in the biopharmaceutical industry with numerous biotechnology and pharmaceutical companies investing heavily in research and development, often requiring advanced protein purification and isolation technologies. Government funding for research and development projects in biotechnology and life sciences supports protein purification technologies, positively impacting the market.
For instance, according to the Government of Canada, 2021, the Government of Canada has invested over $1.2 billion to rebuild Canada’s vaccine, therapeutics and biomanufacturing capacity. The Government launched the Biomanufacturing and Life Sciences Strategy. This means more than $2.2 billion over seven years from Budget 2021 to continue growing a strong and competitive sector.
Competitive Landscape
The major global players in the protein purification & isolation market include Thermo Fisher Scientific Inc., Merck KGaA, QIAGEN N.V., Bio-Rad Laboratories, Inc., GE HealthCare, F. Hoffmann-La Roche Ltd, Promega Corporation, Norgen Biotek Corp., Takara Bio Inc. and Abcam plc. among others.
COVID-19 Impact Analysis
The COVID-19 pandemic significantly impacted the global protein purification & isolation market. The pandemic has shifted research focus in life sciences and biotechnology to virology, immunology and infectious diseases, potentially impacting demand for specific proteins and purification techniques. The pandemic also disrupted the supply chain of these protein purification equipments and kits globally.
Market Segmentation
By Product Type
• Instruments
• Consumables
o Kits
o Reagents
o Columns
o Others
By Technology
• Ultrafiltration
• Precipitation
• Chromatography
o Ion Exchange Chromatography
o Size Exclusion Chromatography
o Reversed Phase Chromatography
o Others
• Electrophoresis
o Gel electrophoresis
o Capillary electrophoresis
o Others
• Western Blotting
• Others
By End-User
• Hospitals
• Academic and Research Institutes
• Pharmaceutical Companies
• Biotechnological Companies
• Others
By Region
• North America
o U.S.
o Canada
o Mexico
• South America
o Brazil
o Argentina
o Rest of South America
• Europe
o Germany
o U.K.
o France
o Spain
o Italy
o Rest of Europe
• Asia-Pacific
o China
o India
o Japan
o Australia
o Rest of Asia-Pacific
• Middle East and Africa
Why Purchase the Report?
• To visualize the global protein purification & isolation market segmentation based on product type, technology, end-user and region as well as understand key commercial assets and players.
• Identify commercial opportunities by analyzing trends and co-development
• Excel data sheet with numerous data points of protein purification & isolation market-level with all segments.
• PDF report consists of a comprehensive analysis after exhaustive qualitative interviews and an in-depth study.
• Product mapping available as excel consisting of key products of all the major players.
The global protein purification & isolation market report would provide approximately 61 tables, 61 figures, and 187 Pages.
Target Audience 2023
• Manufacturers/ Buyers
• Industry Investors/Investment Bankers
• Research Professionals
• Emerging Companies

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Table of Contents

1. Methodology and Scope
1.1. Research Methodology
1.2. Research Objective and Scope of the Report
2. Definition and Overview
3. Executive Summary
3.1. Snippet by Product Type
3.2. Snippet by Technology
3.3. Snippet by End-User
3.4. Snippet by Region
4. Dynamics
4.1. Impacting Factors
4.1.1. Drivers
4.1.1.1. Increasing Demand for Accurate and Rapid Purification Technologies
4.1.2. Restraints
4.1.2.1. High Cost Associated with the Protein Purification Kits
4.1.3. Opportunity
4.1.4. Impact Analysis
5. Industry Analysis
5.1. Porter's Five Force Analysis
5.2. Supply Chain Analysis
5.3. Pricing Analysis
5.4. Regulatory Analysis
5.5. Unmet Needs
5.6. Patent Analysis
5.7. SWOT Analysis
5.8. PESTEL Analysis
5.9. Technology and Trend Analysis
6. COVID-19 Analysis
6.1. Analysis of COVID-19
6.1.1. Scenario Before COVID
6.1.2. Scenario During COVID
6.1.3. Scenario Post COVID
6.2. Pricing Dynamics Amid COVID-19
6.3. Demand-Supply Spectrum
6.4. Government Initiatives Related to the Market During the Pandemic
6.5. Manufacturers Strategic Initiatives
6.6. Conclusion
7. By Product Type
7.1. Introduction
7.1.1. Market Size Analysis and Y-o-Y Growth Analysis (%), By Product Type
7.1.2. Market Attractiveness Index, By Product Type
7.2. Instruments*
7.2.1. Introduction
7.2.2. Market Size Analysis and Y-o-Y Growth Analysis (%)
7.3. Consumables
7.3.1. Kits
7.3.2. Reagents
7.3.3. Columns
7.3.4. Others
8. By Technology
8.1. Introduction
8.1.1. Market Size Analysis and Y-o-Y Growth Analysis (%), By Technology
8.1.2. Market Attractiveness Index, By Technology
8.2. Ultrafiltration*
8.2.1. Introduction
8.2.2. Market Size Analysis and Y-o-Y Growth Analysis (%)
8.3. Precipitation
8.4. Chromatography
8.4.1. Ion Exchange Chromatography
8.4.2. Size Exclusion Chromatography
8.4.3. Reversed Phase Chromatography
8.4.4. Others
8.5. Electrophoresis
8.5.1. Gel electrophoresis
8.5.2. Capillary electrophoresis
8.5.3. Others
8.6. Western Blotting
8.7. Others
9. By End-User
9.1. Introduction
9.1.1. Market Size Analysis and Y-o-Y Growth Analysis (%), By End-User
9.1.2. Market Attractiveness Index, By End-User
9.2. Hospitals*
9.2.1. Introduction
9.2.2. Market Size Analysis and Y-o-Y Growth Analysis (%)
9.3. Academic and Research Institutes
9.4. Pharmaceutical Companies
9.5. Biotechnological Companies
9.6. Others
10. By Region
10.1. Introduction
10.1.1. Market Size Analysis and Y-o-Y Growth Analysis (%), By Region
10.1.2. Market Attractiveness Index, By Region
10.2. North America
10.2.1. Introduction
10.2.2. Key Region-Specific Dynamics
10.2.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Product Type
10.2.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Technology
10.2.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By End-User
10.2.6. Market Size Analysis and Y-o-Y Growth Analysis (%), By Country
10.2.6.1. U.S.
10.2.6.2. Canada
10.2.6.3. Mexico
10.3. Europe
10.3.1. Introduction
10.3.2. Key Region-Specific Dynamics
10.3.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Product Type
10.3.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Technology
10.3.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By End-User
10.3.6. Market Size Analysis and Y-o-Y Growth Analysis (%), By Country
10.3.6.1. Germany
10.3.6.2. UK
10.3.6.3. France
10.3.6.4. Italy
10.3.6.5. Spain
10.3.6.6. Rest of Europe
10.4. South America
10.4.1. Introduction
10.4.2. Key Region-Specific Dynamics
10.4.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Product Type
10.4.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Technology
10.4.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By End-User
10.4.6. Market Size Analysis and Y-o-Y Growth Analysis (%), By Country
10.4.6.1. Brazil
10.4.6.2. Argentina
10.4.6.3. Rest of South America
10.5. Asia-Pacific
10.5.1. Introduction
10.5.2. Key Region-Specific Dynamics
10.5.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Product Type
10.5.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Technology
10.5.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By End-User
10.5.6. Market Size Analysis and Y-o-Y Growth Analysis (%), By Country
10.5.6.1. China
10.5.6.2. India
10.5.6.3. Japan
10.5.6.4. Australia
10.5.6.5. Rest of Asia-Pacific
10.6. Middle East and Africa
10.6.1. Introduction
10.6.2. Key Region-Specific Dynamics
10.6.3. Market Size Analysis and Y-o-Y Growth Analysis (%), By Product Type
10.6.4. Market Size Analysis and Y-o-Y Growth Analysis (%), By Technology
10.6.5. Market Size Analysis and Y-o-Y Growth Analysis (%), By End-User
11. Competitive Landscape
11.1. Competitive Scenario
11.2. Market Positioning/Share Analysis
11.3. Mergers and Acquisitions Analysis
12. Company Profiles
12.1. Thermo Fisher Scientific Inc.*
12.1.1. Company Overview
12.1.2. Product Portfolio and Description
12.1.3. Financial Overview
12.1.4. Key Developments
12.2. Merck KGaA
12.3. QIAGEN N.V.
12.4. Bio-Rad Laboratories, Inc.
12.5. GE HealthCare
12.6. F. Hoffmann-La Roche Ltd
12.7. Promega Corporation
12.8. Norgen Biotek Corp.
12.9. Takara Bio Inc.
12.10. Abcam plc.
LIST NOT EXHAUSTIVE
13. Appendix
13.1. About Us and Services
13.2. Contact Us