Summary

The 7 major upper limb hypotonia markets are expected to exhibit a CAGR of 3.3% during 2024-2034.

The upper limb hypotonia market has been comprehensively analyzed in IMARC's new report titled "Upper Limb Hypotonia Market: Epidemiology, Industry Trends, Share, Size, Growth, Opportunity, and Forecast 2024-2034". Upper limb hypotonia refers to a condition where there is a decreased muscle tone or tension in the muscles of the upper limb, including the arm, forearm, and hand. This can result in reduced strength and coordination of the upper limb, as well as difficulty performing tasks requiring fine motor skills, such as writing. The most common symptoms associated with the ailment include decreased muscle tone and strength, poor reflexes, hyper flexibility, speech difficulties, reduced activity endurance, impaired posture, etc. In infants, the disease manifests as poor or no head control, delay in motor skills development, like crawling, and slowed growth of fine motor abilities, including difficulty holding anything. The diagnosis of upper limb hypotonia typically requires a review of the patient's symptoms, medical history, and a physical exam. The healthcare provider may perform other imaging tests, including an electromyogram, MRI, or CT scan, to measure nerve and muscle functioning

The rising prevalence of upper motor neuron lesions, which may result from disease, injury, or conditions that damage the central nervous system, is primarily driving the upper limb hypotonia market. In addition to this, the increasing incidences of genetic disorders, such as Down syndrome, Prader-Willi syndrome, Tay-Sachs disease, trisomy 13, etc., are also bolstering the market growth. Moreover, the widespread adoption of muscle relaxants, including baclofen, diazepam, dantrolene, etc., to reduce muscle spasticity and enhance patients' quality of life, is acting as another significant growth-inducing factor. Apart from this, the inflating application of physical, occupational, and speech therapy, which aids in gaining muscle tone, stabilizing mobility, and preventing delayed growth, is further propelling the upper limb hypotonia market. Additionally, multiple key players are making extensive investments in R&D activities to launch novel regimens that can alter nerve conduction and improve functionality among patients. This, in turn, is also creating a positive outlook for the market. Furthermore, the emerging popularity of extracorporeal shock wave therapy for treating the ailment, since it involves the delivery of acoustic shockwaves to break up soft tissue calcifications, enhance blood circulation, and release growth factors, is expected to drive the upper limb hypotonia market in the coming years.

IMARC Group's new report provides an exhaustive analysis of the upper limb hypotonia market in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan. This includes treatment practices, in-market, and pipeline drugs, share of individual therapies, market performance across the seven major markets, market performance of key companies and their drugs, etc. The report also provides the current and future patient pool across the seven major markets. According to the report the United States has the largest patient pool for upper limb hypotonia and also represents the largest market for its treatment. Furthermore, the current treatment practice/algorithm, market drivers, challenges, opportunities, reimbursement scenario and unmet medical needs, etc. have also been provided in the report. This report is a must-read for manufacturers, investors, business strategists, researchers, consultants, and all those who have any kind of stake or are planning to foray into the upper limb hypotonia market in any manner.

Time Period of the Study

Base Year: 2023
Historical Period: 2018-2023
Market Forecast: 2024-2034

Countries Covered

United States
Germany
France
United Kingdom
Italy
Spain
Japan

Analysis Covered Across Each Country

Historical, current, and future epidemiology scenario
Historical, current, and future performance of the upper limb hypotonia market
Historical, current, and future performance of various therapeutic categories in the market
Sales of various drugs across the upper limb hypotonia market
Reimbursement scenario in the market
In-market and pipeline drugs
Competitive Landscape:
This report also provides a detailed analysis of the current upper limb hypotonia marketed drugs and late-stage pipeline drugs.

In-Market Drugs

Drug Overview
Mechanism of Action
Regulatory Status
Clinical Trial Results
Drug Uptake and Market Performance

Late-Stage Pipeline Drugs

Drug Overview
Mechanism of Action
Regulatory Status
Clinical Trial Results
Drug Uptake and Market Performance

*Kindly note that the drugs in the above table only represent a partial list of marketed/pipeline drugs, and the complete list has been provided in the report.

Key Questions Answered in this Report:
Market Insights

How has the upper limb hypotonia market performed so far and how will it perform in the coming years?
What are the markets shares of various therapeutic segments in 2023 and how are they expected to perform till 2034?
What was the country-wise size of the upper limb hypotonia market across the seven major markets in 2023 and what will it look like in 2034?
What is the growth rate of the upper limb hypotonia market across the seven major markets and what will be the expected growth over the next ten years?
What are the key unmet needs in the market?

Epidemiology Insights

What is the number of prevalent cases (2018-2034) of upper limb hypotonia across the seven major markets?
What is the number of prevalent cases (2018-2034) of upper limb hypotonia by age across the seven major markets?
What is the number of prevalent cases (2018-2034) of upper limb hypotonia by gender across the seven major markets?
How many patients are diagnosed (2018-2034) with upper limb hypotonia across the seven major markets?
What is the size of the upper limb hypotonia patient pool (2018-2023) across the seven major markets?
What would be the forecasted patient pool (2024-2034) across the seven major markets?
What are the key factors driving the epidemiological trend of upper limb hypotonia?
What will be the growth rate of patients across the seven major markets?

Upper Limb Hypotonia: Current Treatment Scenario, Marketed Drugs and Emerging Therapies

What are the current marketed drugs and what are their market performance?
What are the key pipeline drugs and how are they expected to perform in the coming years?
How safe are the current marketed drugs and what are their efficacies?
How safe are the late-stage pipeline drugs and what are their efficacies?
What are the current treatment guidelines for upper limb hypotonia drugs across the seven major markets?
Who are the key companies in the market and what are their market shares?
What are the key mergers and acquisitions, licensing activities, collaborations, etc. related to the upper limb hypotonia market?
What are the key regulatory events related to the upper limb hypotonia market?
What is the structure of clinical trial landscape by status related to the upper limb hypotonia market?
What is the structure of clinical trial landscape by phase related to the upper limb hypotonia market?
What is the structure of clinical trial landscape by route of administration related to the upper limb hypotonia market?

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Table of Contents

1 Preface

2 Scope and Methodology
2.1 Objectives of the Study
2.2 Stakeholders
2.3 Data Sources
2.3.1 Primary Sources
2.3.2 Secondary Sources
2.4 Market Estimation
2.4.1 Bottom-Up Approach
2.4.2 Top-Down Approach
2.5 Forecasting Methodology

3 Executive Summary

4 Upper Limb Hypotonia - Introduction
4.1 Overview
4.2 Regulatory Process
4.3 Epidemiology (2018-2023) and Forecast (2024-2034)
4.4 Market Overview (2018-2023) and Forecast (2024-2034)
4.5 Competitive Intelligence

5 Upper Limb Hypotonia - Disease Overview
5.1 Introduction
5.2 Symptoms and Diagnosis
5.3 Pathophysiology
5.4 Causes and Risk Factors
5.5 Treatment

6 Patient Journey

7 Upper Limb Hypotonia - Epidemiology and Patient Population
7.1 Epidemiology - Key Insights
7.2 Epidemiology Scenario - Top 7 Markets
7.2.1 Epidemiology Scenario (2018-2023)
7.2.2 Epidemiology Forecast (2024-2034)
7.2.3 Epidemiology by Age (2018-2034)
7.2.4 Epidemiology by Gender (2018-2034)
7.2.5 Diagnosed Cases (2018-2034)
7.2.6 Patient Pool/Treated Cases (2018-2034)
7.3 Epidemiology Scenario - United States
7.3.1 Epidemiology Scenario (2018-2023)
7.3.2 Epidemiology Forecast (2024-2034)
7.3.3 Epidemiology by Age (2018-2034)
7.3.4 Epidemiology by Gender (2018-2034)
7.3.5 Diagnosed Cases (2018-2034)
7.3.6 Patient Pool/Treated Cases (2018-2034)
7.4 Epidemiology Scenario - Germany
7.4.1 Epidemiology Scenario (2018-2023)
7.4.2 Epidemiology Forecast (2024-2034)
7.4.3 Epidemiology by Age (2018-2034)
7.4.4 Epidemiology by Gender (2018-2034)
7.4.5 Diagnosed Cases (2018-2034)
7.4.6 Patient Pool/Treated Cases (2018-2034)
7.5 Epidemiology Scenario - France
7.5.1 Epidemiology Scenario (2018-2023)
7.5.2 Epidemiology Forecast (2024-2034)
7.5.3 Epidemiology by Age (2018-2034)
7.5.4 Epidemiology by Gender (2018-2034)
7.5.5 Diagnosed Cases (2018-2034)
7.5.6 Patient Pool/Treated Cases (2018-2034)
7.6 Epidemiology Scenario - United Kingdom
7.6.1 Epidemiology Scenario (2018-2023)
7.6.2 Epidemiology Forecast (2024-2034)
7.6.3 Epidemiology by Age (2018-2034)
7.6.4 Epidemiology by Gender (2018-2034)
7.6.5 Diagnosed Cases (2018-2034)
7.6.6 Patient Pool/Treated Cases (2018-2034)
7.7 Epidemiology Scenario - Italy
7.7.1 Epidemiology Scenario (2018-2023)
7.7.2 Epidemiology Forecast (2024-2034)
7.7.3 Epidemiology by Age (2018-2034)
7.7.4 Epidemiology by Gender (2018-2034)
7.7.5 Diagnosed Cases (2018-2034)
7.7.6 Patient Pool/Treated Cases (2018-2034)
7.8 Epidemiology Scenario - Spain
7.8.1 Epidemiology Scenario (2018-2023)
7.8.2 Epidemiology Forecast (2024-2034)
7.8.3 Epidemiology by Age (2018-2034)
7.8.4 Epidemiology by Gender (2018-2034)
7.8.5 Diagnosed Cases (2018-2034)
7.8.6 Patient Pool/Treated Cases (2018-2034)
7.9 Epidemiology Scenario - Japan
7.9.1 Epidemiology Scenario (2018-2023)
7.9.2 Epidemiology Forecast (2024-2034)
7.9.3 Epidemiology by Age (2018-2034)
7.9.4 Epidemiology by Gender (2018-2034)
7.9.5 Diagnosed Cases (2018-2034)
7.9.6 Patient Pool/Treated Cases (2018-2034)

8 Upper Limb Hypotonia - Treatment Algorithm, Guidelines, and Medical Practices
8.1 Guidelines, Management and Treatment
8.2 Treatment Algorithm

9 Upper Limb Hypotonia - Unmet Needs

10 Upper Limb Hypotonia - Key Endpoints of Treatment

11 Upper Limb Hypotonia - Marketed Products
11.1 List of Upper Limb Hypotonia Marketed Drugs Across the Top 7 Markets
11.1.1 BOTOX (OnabotulinumtoxinA) - AbbVie
11.1.1.1 Drug Overview
11.1.1.2 Mechanism of Action
11.1.1.3 Regulatory Status
11.1.1.4 Clinical Trial Results
11.1.1.5 Sales Across Major Markets
11.1.2 Dysport (AbobotulinumtoxinA) - Ipsen
11.1.2.1 Drug Overview
11.1.2.2 Mechanism of Action
11.1.2.3 Regulatory Status
11.1.2.4 Clinical Trial Results
11.1.2.5 Sales Across Major Markets
11.1.3 Xeomin (IncobotulinumtoxinA) - Merz Pharma
11.1.3.1 Drug Overview
11.1.3.2 Mechanism of Action
11.1.3.3 Regulatory Status
11.1.3.4 Clinical Trial Results
11.1.3.5 Sales Across Major Markets

Kindly note that the above only represents a partial list of marketed drugs, and the complete list has been provided in the report.

12 Upper Limb Hypotonia - Pipeline Drugs
12.1 List of Upper Limb Hypotonia Pipeline Drugs Across the Top 7 Markets
12.1.1 Daxxify - Revance Therapeutics
12.1.1.1 Drug Overview
12.1.1.2 Mechanism of Action
12.1.1.3 Clinical Trial Results
12.1.1.4 Safety and Efficacy
12.1.1.5 Regulatory Status
12.1.2 IPN 10200 - Ipsen
12.1.2.1 Drug Overview
12.1.2.2 Mechanism of Action
12.1.2.3 Clinical Trial Results
12.1.2.4 Safety and Efficacy
12.1.2.5 Regulatory Status

Kindly note that the above only represents a partial list of pipeline drugs, and the complete list has been provided in the report.

13. Upper Limb Hypotonia - Attribute Analysis of Key Marketed and Pipeline Drugs

14. Upper Limb Hypotonia – Clinical Trial Landscape
14.1 Drugs by Status
14.2 Drugs by Phase
14.3 Drugs by Route of Administration
14.4 Key Regulatory Events

15 Upper Limb Hypotonia - Market Scenario
15.1 Market Scenario - Key Insights
15.2 Market Scenario - Top 7 Markets
15.2.1 Upper Limb Hypotonia - Market Size
15.2.1.1 Market Size (2018-2023)
15.2.1.2 Market Forecast (2024-2034)
15.2.2 Upper Limb Hypotonia - Market Size by Therapies
15.2.2.1 Market Size by Therapies (2018-2023)
15.2.2.2 Market Forecast by Therapies (2024-2034)
15.3 Market Scenario - United States
15.3.1 Upper Limb Hypotonia - Market Size
15.3.1.1 Market Size (2018-2023)
15.3.1.2 Market Forecast (2024-2034)
15.3.2 Upper Limb Hypotonia - Market Size by Therapies
15.3.2.1 Market Size by Therapies (2018-2023)
15.3.2.2 Market Forecast by Therapies (2024-2034)
15.3.3 Upper Limb Hypotonia - Access and Reimbursement Overview
15.4 Market Scenario - Germany
15.4.1 Upper Limb Hypotonia - Market Size
15.4.1.1 Market Size (2018-2023)
15.4.1.2 Market Forecast (2024-2034)
15.4.2 Upper Limb Hypotonia - Market Size by Therapies
15.4.2.1 Market Size by Therapies (2018-2023)
15.4.2.2 Market Forecast by Therapies (2024-2034)
15.4.3 Upper Limb Hypotonia - Access and Reimbursement Overview
15.5 Market Scenario - France
15.5.1 Upper Limb Hypotonia - Market Size
15.5.1.1 Market Size (2018-2023)
15.5.1.2 Market Forecast (2024-2034)
15.5.2 Upper Limb Hypotonia - Market Size by Therapies
15.5.2.1 Market Size by Therapies (2018-2023)
15.5.2.2 Market Forecast by Therapies (2024-2034)
15.5.3 Upper Limb Hypotonia - Access and Reimbursement Overview
15.6 Market Scenario - United Kingdom
15.6.1 Upper Limb Hypotonia - Market Size
15.6.1.1 Market Size (2018-2023)
15.6.1.2 Market Forecast (2024-2034)
15.6.2 Upper Limb Hypotonia - Market Size by Therapies
15.6.2.1 Market Size by Therapies (2018-2023)
15.6.2.2 Market Forecast by Therapies (2024-2034)
15.6.3 Upper Limb Hypotonia - Access and Reimbursement Overview
15.7 Market Scenario - Italy
15.7.1 Upper Limb Hypotonia - Market Size
15.7.1.1 Market Size (2018-2023)
15.7.1.2 Market Forecast (2024-2034)
15.7.2 Upper Limb Hypotonia - Market Size by Therapies
15.7.2.1 Market Size by Therapies (2018-2023)
15.7.2.2 Market Forecast by Therapies (2024-2034)
15.7.3 Upper Limb Hypotonia - Access and Reimbursement Overview
15.8 Market Scenario - Spain
15.8.1 Upper Limb Hypotonia - Market Size
15.8.1.1 Market Size (2018-2023)
15.8.1.2 Market Forecast (2024-2034)
15.8.2 Upper Limb Hypotonia - Market Size by Therapies
15.8.2.1 Market Size by Therapies (2018-2023)
15.8.2.2 Market Forecast by Therapies (2024-2034)
15.8.3 Upper Limb Hypotonia - Access and Reimbursement Overview
15.9 Market Scenario - Japan
15.9.1 Upper Limb Hypotonia - Market Size
15.9.1.1 Market Size (2018-2023)
15.9.1.2 Market Forecast (2024-2034)
15.9.2 Upper Limb Hypotonia - Market Size by Therapies
15.9.2.1 Market Size by Therapies (2018-2023)
15.9.2.2 Market Forecast by Therapies (2024-2034)
15.9.3 Upper Limb Hypotonia - Access and Reimbursement Overview

16 Upper Limb Hypotonia - Recent Events and Inputs From Key Opinion Leaders

17 Upper Limb Hypotonia Market - SWOT Analysis
17.1 Strengths
17.2 Weaknesses
17.3 Opportunities
17.4 Threats

18 Upper Limb Hypotonia Market – Strategic Recommendations

19 Appendix