Summary

The 7 major erythromelalgia markets reached a value of US$ 1.7 Billion in 2023. Looking forward, IMARC Group expects the 7MM to reach US$ 2.8 Billion by 2034, exhibiting a growth rate (CAGR) of 4.94% during 2024-2034.

The erythromelalgia market has been comprehensively analyzed in IMARC's new report titled "Erythromelalgia Market: Epidemiology, Industry Trends, Share, Size, Growth, Opportunity, and Forecast 2024-2034". Erythromelalgia is a neurovascular disorder characterized by a distinct set of symptoms that primarily affect the extremities, particularly the feet and hands. The indications can vary in intensity and duration but are generally episodic and recurrent. Some common symptoms include episodes of intense burning pain, redness (erythema), increased temperature, swelling in the affected areas, typically the feet and hands, etc. Individuals with erythromelalgia may also experience heightened sensitivity to touch, throbbing or pulsating sensations, and emotional distress due to the chronic nature of the condition. The diagnosis of erythromelalgia typically involves a comprehensive evaluation of the individual's medical history, a thorough physical examination, and consideration of specific diagnostic criteria. The healthcare provider will assess the patient's symptoms, including the frequency and duration of episodes, as well as any triggers or relieving factors. A physical examination may reveal signs of redness and warmth during an episode. Several diagnostic procedures, including blood tests, are conducted to rule out underlying conditions, such as autoimmune disorders or blood clotting abnormalities. Additionally, nerve conduction studies and skin biopsies are also performed to evaluate nerve function and assess for small fiber neuropathy, which can be associated with erythromelalgia.

The rising cases of mutations in genes that encode ion channels, particularly sodium channels, resulting in an increased neuronal excitability and pain transmission, are primarily driving the erythromelalgia market. In addition to this, the growing prevalence of numerous associated risk factors, such as myeloproliferative disorders, nerve entrapment, autoimmune diseases, vasculitis, exposure to warm temperatures, etc., is also augmenting the market growth. Furthermore, the widespread adoption of several medications, including anticonvulsants and tricyclic antidepressants, to help modulate nerve signaling and provide relief from neuropathic pain is acting as another significant growth-inducing factor. Moreover, various key players are investing in R&D activities to investigate the use of biologics, such as tumor necrosis factor (TNF) inhibitors or interleukin-1 (IL-1) inhibitors, which target specific molecules involved in the inflammatory response. This, in turn, is creating a positive outlook for the market. Additionally, the ongoing advancements in imaging technologies, including the introduction of laser Doppler imaging, that can help quantify the extent of blood flow abnormalities, thereby aiding in the diagnosis and monitoring of the ailment, are expected to drive the erythromelalgia market in the coming years.

IMARC Group's new report provides an exhaustive analysis of the erythromelalgia market in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan. This includes treatment practices, in-market, and pipeline drugs, share of individual therapies, market performance across the seven major markets, market performance of key companies and their drugs, etc. The report also provides the current and future patient pool across the seven major markets. According to the report the United States has the largest patient pool for erythromelalgia and also represents the largest market for its treatment. Furthermore, the current treatment practice/algorithm, market drivers, challenges, opportunities, reimbursement scenario and unmet medical needs, etc. have also been provided in the report. This report is a must-read for manufacturers, investors, business strategists, researchers, consultants, and all those who have any kind of stake or are planning to foray into the erythromelalgia market in any manner.

Time Period of the Study

Base Year: 2023
Historical Period: 2018-2023
Market Forecast: 2024-2034

Countries Covered

United States
Germany
France
United Kingdom
Italy
Spain
Japan

Analysis Covered Across Each Country

Historical, current, and future epidemiology scenario
Historical, current, and future performance of the erythromelalgia market
Historical, current, and future performance of various therapeutic categories in the market
Sales of various drugs across the erythromelalgia market
Reimbursement scenario in the market
In-market and pipeline drugs
Competitive Landscape:
This report also provides a detailed analysis of the current erythromelalgia marketed drugs and late-stage pipeline drugs.

In-Market Drugs

Drug Overview
Mechanism of Action
Regulatory Status
Clinical Trial Results
Drug Uptake and Market Performance

Late-Stage Pipeline Drugs

Drug Overview
Mechanism of Action
Regulatory Status
Clinical Trial Results
Drug Uptake and Market Performance

*Kindly note that the drugs in the above table only represent a partial list of marketed/pipeline drugs, and the complete list has been provided in the report.

Key Questions Answered in this Report:
Market Insights

How has the erythromelalgia market performed so far and how will it perform in the coming years?
What are the markets shares of various therapeutic segments in 2023 and how are they expected to perform till 2034?
What was the country-wise size of the erythromelalgia market across the seven major markets in 2023 and what will it look like in 2034?
What is the growth rate of the erythromelalgia market across the seven major markets and what will be the expected growth over the next ten years?
What are the key unmet needs in the market?

Epidemiology Insights

What is the number of prevalent cases (2018-2034) of erythromelalgia across the seven major markets?
What is the number of prevalent cases (2018-2034) of erythromelalgia by age across the seven major markets?
What is the number of prevalent cases (2018-2034) of erythromelalgia by gender across the seven major markets?
How many patients are diagnosed (2018-2034) with erythromelalgia across the seven major markets?
What is the size of the erythromelalgia patient pool (2018-2023) across the seven major markets?
What would be the forecasted patient pool (2024-2034) across the seven major markets?
What are the key factors driving the epidemiological trend of erythromelalgia?
What will be the growth rate of patients across the seven major markets?

Erythromelalgia: Current Treatment Scenario, Marketed Drugs and Emerging Therapies

What are the current marketed drugs and what are their market performance?
What are the key pipeline drugs and how are they expected to perform in the coming years?
How safe are the current marketed drugs and what are their efficacies?
How safe are the late-stage pipeline drugs and what are their efficacies?
What are the current treatment guidelines for erythromelalgia drugs across the seven major markets?
Who are the key companies in the market and what are their market shares?
What are the key mergers and acquisitions, licensing activities, collaborations, etc. related to the erythromelalgia market?
What are the key regulatory events related to the erythromelalgia market?
What is the structure of clinical trial landscape by status related to the erythromelalgia market?
What is the structure of clinical trial landscape by phase related to the erythromelalgia market?
What is the structure of clinical trial landscape by route of administration related to the erythromelalgia market?

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Table of Contents

1 Preface

2 Scope and Methodology
2.1 Objectives of the Study
2.2 Stakeholders
2.3 Data Sources
2.3.1 Primary Sources
2.3.2 Secondary Sources
2.4 Market Estimation
2.4.1 Bottom-Up Approach
2.4.2 Top-Down Approach
2.5 Forecasting Methodology

3 Executive Summary

4 Erythromelalgia - Introduction
4.1 Overview
4.2 Regulatory Process
4.3 Epidemiology (2018-2023) and Forecast (2024-2034)
4.4 Market Overview (2018-2023) and Forecast (2024-2034)
4.5 Competitive Intelligence

5 Erythromelalgia - Disease Overview
5.1 Introduction
5.2 Symptoms and Diagnosis
5.3 Pathophysiology
5.4 Causes and Risk Factors
5.5 Treatment

6 Patient Journey

7 Erythromelalgia - Epidemiology and Patient Population
7.1 Epidemiology - Key Insights
7.2 Epidemiology Scenario - Top 7 Markets
7.2.1 Epidemiology Scenario (2018-2023)
7.2.2 Epidemiology Forecast (2024-2034)
7.2.3 Epidemiology by Age (2018-2034)
7.2.4 Epidemiology by Gender (2018-2034)
7.2.5 Diagnosed Cases (2018-2034)
7.2.6 Patient Pool/Treated Cases (2018-2034)
7.3 Epidemiology Scenario - United States
7.3.1 Epidemiology Scenario (2018-2023)
7.3.2 Epidemiology Forecast (2024-2034)
7.3.3 Epidemiology by Age (2018-2034)
7.3.4 Epidemiology by Gender (2018-2034)
7.3.5 Diagnosed Cases (2018-2034)
7.3.6 Patient Pool/Treated Cases (2018-2034)
7.4 Epidemiology Scenario - Germany
7.4.1 Epidemiology Scenario (2018-2023)
7.4.2 Epidemiology Forecast (2024-2034)
7.4.3 Epidemiology by Age (2018-2034)
7.4.4 Epidemiology by Gender (2018-2034)
7.4.5 Diagnosed Cases (2018-2034)
7.4.6 Patient Pool/Treated Cases (2018-2034)
7.5 Epidemiology Scenario - France
7.5.1 Epidemiology Scenario (2018-2023)
7.5.2 Epidemiology Forecast (2024-2034)
7.5.3 Epidemiology by Age (2018-2034)
7.5.4 Epidemiology by Gender (2018-2034)
7.5.5 Diagnosed Cases (2018-2034)
7.5.6 Patient Pool/Treated Cases (2018-2034)
7.6 Epidemiology Scenario - United Kingdom
7.6.1 Epidemiology Scenario (2018-2023)
7.6.2 Epidemiology Forecast (2024-2034)
7.6.3 Epidemiology by Age (2018-2034)
7.6.4 Epidemiology by Gender (2018-2034)
7.6.5 Diagnosed Cases (2018-2034)
7.6.6 Patient Pool/Treated Cases (2018-2034)
7.7 Epidemiology Scenario - Italy
7.7.1 Epidemiology Scenario (2018-2023)
7.7.2 Epidemiology Forecast (2024-2034)
7.7.3 Epidemiology by Age (2018-2034)
7.7.4 Epidemiology by Gender (2018-2034)
7.7.5 Diagnosed Cases (2018-2034)
7.7.6 Patient Pool/Treated Cases (2018-2034)
7.8 Epidemiology Scenario - Spain
7.8.1 Epidemiology Scenario (2018-2023)
7.8.2 Epidemiology Forecast (2024-2034)
7.8.3 Epidemiology by Age (2018-2034)
7.8.4 Epidemiology by Gender (2018-2034)
7.8.5 Diagnosed Cases (2018-2034)
7.8.6 Patient Pool/Treated Cases (2018-2034)
7.9 Epidemiology Scenario - Japan
7.9.1 Epidemiology Scenario (2018-2023)
7.9.2 Epidemiology Forecast (2024-2034)
7.9.3 Epidemiology by Age (2018-2034)
7.9.4 Epidemiology by Gender (2018-2034)
7.9.5 Diagnosed Cases (2018-2034)
7.9.6 Patient Pool/Treated Cases (2018-2034)

8 Erythromelalgia - Treatment Algorithm, Guidelines, and Medical Practices
8.1 Guidelines, Management and Treatment
8.2 Treatment Algorithm

9 Erythromelalgia - Unmet Needs

10 Erythromelalgia - Key Endpoints of Treatment

11 Erythromelalgia - Marketed Products
11.1 List of Erythromelalgia Marketed Drugs Across the Top 7 Markets
11.1.1 Drug Name – Company Name
11.1.1.1 Drug Overview
11.1.1.2 Mechanism of Action
11.1.1.3 Regulatory Status
11.1.1.4 Clinical Trial Results
11.1.1.5 Sales Across Major Markets

Kindly note that the complete list of marketed drugs has been provided in the report.

12 Erythromelalgia - Pipeline Drugs
12.1 List of Erythromelalgia Pipeline Drugs Across the Top 7 Markets
12.1.1 BIIB074 - Biogen
12.1.1.1 Drug Overview
12.1.1.2 Mechanism of Action
12.1.1.3 Clinical Trial Results
12.1.1.4 Safety and Efficacy
12.1.1.5 Regulatory Status

Kindly note that the above only represents a partial list of pipeline drugs, and the complete list has been provided in the report.

13. Erythromelalgia - Attribute Analysis of Key Marketed and Pipeline Drugs

14. Erythromelalgia – Clinical Trial Landscape
14.1 Drugs by Status
14.2 Drugs by Phase
14.3 Drugs by Route of Administration
14.4 Key Regulatory Events

15 Erythromelalgia - Market Scenario
15.1 Market Scenario - Key Insights
15.2 Market Scenario - Top 7 Markets
15.2.1 Erythromelalgia - Market Size
15.2.1.1 Market Size (2018-2023)
15.2.1.2 Market Forecast (2024-2034)
15.2.2 Erythromelalgia - Market Size by Therapies
15.2.2.1 Market Size by Therapies (2018-2023)
15.2.2.2 Market Forecast by Therapies (2024-2034)
15.3 Market Scenario - United States
15.3.1 Erythromelalgia - Market Size
15.3.1.1 Market Size (2018-2023)
15.3.1.2 Market Forecast (2024-2034)
15.3.2 Erythromelalgia - Market Size by Therapies
15.3.2.1 Market Size by Therapies (2018-2023)
15.3.2.2 Market Forecast by Therapies (2024-2034)
15.3.3 Erythromelalgia - Access and Reimbursement Overview
15.4 Market Scenario - Germany
15.4.1 Erythromelalgia - Market Size
15.4.1.1 Market Size (2018-2023)
15.4.1.2 Market Forecast (2024-2034)
15.4.2 Erythromelalgia - Market Size by Therapies
15.4.2.1 Market Size by Therapies (2018-2023)
15.4.2.2 Market Forecast by Therapies (2024-2034)
15.4.3 Erythromelalgia - Access and Reimbursement Overview
15.5 Market Scenario - France
15.5.1 Erythromelalgia - Market Size
15.5.1.1 Market Size (2018-2023)
15.5.1.2 Market Forecast (2024-2034)
15.5.2 Erythromelalgia - Market Size by Therapies
15.5.2.1 Market Size by Therapies (2018-2023)
15.5.2.2 Market Forecast by Therapies (2024-2034)
15.5.3 Erythromelalgia - Access and Reimbursement Overview
15.6 Market Scenario - United Kingdom
15.6.1 Erythromelalgia - Market Size
15.6.1.1 Market Size (2018-2023)
15.6.1.2 Market Forecast (2024-2034)
15.6.2 Erythromelalgia - Market Size by Therapies
15.6.2.1 Market Size by Therapies (2018-2023)
15.6.2.2 Market Forecast by Therapies (2024-2034)
15.6.3 Erythromelalgia - Access and Reimbursement Overview
15.7 Market Scenario - Italy
15.7.1 Erythromelalgia - Market Size
15.7.1.1 Market Size (2018-2023)
15.7.1.2 Market Forecast (2024-2034)
15.7.2 Erythromelalgia - Market Size by Therapies
15.7.2.1 Market Size by Therapies (2018-2023)
15.7.2.2 Market Forecast by Therapies (2024-2034)
15.7.3 Erythromelalgia - Access and Reimbursement Overview
15.8 Market Scenario - Spain
15.8.1 Erythromelalgia - Market Size
15.8.1.1 Market Size (2018-2023)
15.8.1.2 Market Forecast (2024-2034)
15.8.2 Erythromelalgia - Market Size by Therapies
15.8.2.1 Market Size by Therapies (2018-2023)
15.8.2.2 Market Forecast by Therapies (2024-2034)
15.8.3 Erythromelalgia - Access and Reimbursement Overview
15.9 Market Scenario - Japan
15.9.1 Erythromelalgia - Market Size
15.9.1.1 Market Size (2018-2023)
15.9.1.2 Market Forecast (2024-2034)
15.9.2 Erythromelalgia - Market Size by Therapies
15.9.2.1 Market Size by Therapies (2018-2023)
15.9.2.2 Market Forecast by Therapies (2024-2034)
15.9.3 Erythromelalgia - Access and Reimbursement Overview

16 Erythromelalgia - Recent Events and Inputs From Key Opinion Leaders

17 Erythromelalgia Market - SWOT Analysis
17.1 Strengths
17.2 Weaknesses
17.3 Opportunities
17.4 Threats

18 Erythromelalgia Market – Strategic Recommendations

19 Appendix