Summary

The global G-protein coupled receptors (GPCRs) market size reached US$ 3.4 Billion in 2023. Looking forward, IMARC Group expects the market to reach US$ 5.7 Billion by 2032, exhibiting a growth rate (CAGR) of 5.69% during 2024-2032. The increasing adoption of GPCRs in drug discovery, the rising number of cancer cases, and extensive research and development (R&D) activities represent some of the key factors driving the market.

G-protein-coupled receptors (GPCRs) are the largest protein family encoded by the human genome. They are signal-transducing molecules that transmit signals to cells and play a key role in converting an extracellular stimulus into intracellular responses. They are located in the cell membrane and are responsible for all physiological processes. GPCRs are cell surface receptors that act like an inbox for messages in the form of lipids, sugars, light energy, peptides, and proteins. These receptors are widely used in the treatment of various diseases, such as inflammatory disorders, metabolic imbalances, cardiac disorders, cancer, and monogenic disorders. As a result, GPCRs are also found in the cell membranes of several organisms, including mammals, plants, microorganisms, and invertebrates.

G-Protein Coupled Receptors (GPCRs) Market Trends:
The increasing adoption of GPCRs in drug discovery across the globe is one of the key factors driving the market growth. In line with this, the widespread utilization of GPCRs in the development of novel pharmaceuticals due to the rising number of cancer cases and lifestyle-related diseases, such as cardiovascular infections and respiratory difficulties, are favoring the market growth. Moreover, the extensive application of GPCRs in several physiological processes as they can be modulated by a wide range of chemical or biological agents due to their cell-surface location is acting as another growth-inducing factor. Apart from this, the integration of automation and innovative technologies with drug development screening procedures to improve their capabilities in therapeutic production is providing an impetus to the market growth. Furthermore, significant developments in effective drug discovery methods, such as advancements in the computational approaches to streamline receptor structure and formulation of new drugs, are propelling the market growth. Additionally, the widespread adoption of GPCRs in oncology and various aspects of cancer biology, such as invasion, migration, and vascular remolding, is providing a considerable boost to the market growth. Besides this, the increasing utilization of GPCRs for decoding metastasis and growth of tumors and developing effective lines of treatment is positively influencing the market growth. Other factors, including extensive research and development (R&D) activities, various automation improvements, the widespread adoption of cyclic Adenosine Monophosphate (cAMP), and the implementation of various government initiatives in the biotechnology and biopharmaceutical sector are anticipated to drive the market growth.

Key Market Segmentation:
IMARC Group provides an analysis of the key trends in each segment of the global G-protein coupled receptors (GPCRs) market, along with forecasts at the global, regional, and country level from 2024-2032. Our report has categorized the market based on product, assay type, and application.

Product Insights:

Cell Lines
Detection Kits
Cell Culture Reagents
Ligands

The report has provided a detailed breakup and analysis of the G-protein coupled receptors (GPCRs) market based on the product. This includes cell lines, detection kits, cell culture reagents and ligands. According to the report, cell lines represented the largest segment.

Assay Type Insights:

cAMP Functional Assays
Calcium Functional Assays
β-Arrestin Functional Assays
Radioligand Binding and GTPγS Functional Assays
Internalization Assays
Trafficking Assays
Others

The report has provided a detailed breakup and analysis of the G-protein coupled receptors (GPCRs) market based on the assay type. This includes cAMP functional, calcium functional, β-Arrestin functional, radioligand binding and GTPγS functional, internalization, and trafficking assays. According to the report, cAMP functional assays represented the largest segment.

Application Insights:

Cancer Research
CNS Research
Metabolic Research
Cardiovascular Research
Inflammation Research
Respiratory Research
Others

The report has provided a detailed breakup and analysis of the G-protein coupled receptors (GPCRs) market based on the application. This includes cancer, CNS, metabolic, cardiovascular, inflammation, respiratory research, and others. According to the report, cancer research represented the largest segment.

Regional Insights:

North America
United States
Canada
Asia Pacific
China
Japan
India
South Korea
Australia
Indonesia
Others
Europe
Germany
France
United Kingdom
Italy
Spain
Russia
Others
Latin America
Brazil
Mexico
Others
Middle East and Africa

The report has also provided a comprehensive analysis of all the major regional markets that include North America (the United States and Canada); Asia Pacific (China, Japan, India, South Korea, Australia, Indonesia, and others); Europe (Germany, France, the United Kingdom, Italy, Spain, Russia, and others); Latin America (Brazil, Mexico, and others); and Middle East and Africa. According to the report, North America was the largest market for G-protein coupled receptors (GPCRs). Some of the factors driving the North America G-protein coupled receptors (GPCRs) market included rising number of cancer cases, extensive research and development (R&D) activities, and various automation improvements.

Competitive Landscape:
The report has also provided a comprehensive analysis of the competitive landscape in the global G-protein coupled receptors (GPCRs) market. Detailed profiles of all major companies have also been provided. Some of the companies covered include Abcam plc, Becton Dickinson and Company, Enzo Biochem Inc., Eurofins DiscoverX Products LLC, HD Biosciences Co. Ltd. (WuXi AppTec), Merck KGaA, Molecular Devices LLC (Danaher Corporation), PerkinElmer Inc., Promega Corporation, Thermo Fisher Scientific Inc., etc.

Key Questions Answered in This Report:
How has the global G-protein coupled receptors (GPCRs) market performed so far and how will it perform in the coming years?
What are the drivers, restraints, and opportunities in the global G-protein coupled receptors (GPCRs) market?
What are the key regional markets?
Which countries represent the most attractive G-protein coupled receptors (GPCRs) markets?
What is the breakup of the market based on the product?
What is the breakup of the market based on the assay type?
What is the breakup of the market based on the application?
What is the competitive structure of the global G-protein coupled receptors (GPCRs) market?
Who are the key players/companies in the global G-protein coupled receptors (GPCRs) market?

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Table of Contents

1 Preface
2 Scope and Methodology
2.1 Objectives of the Study
2.2 Stakeholders
2.3 Data Sources
2.3.1 Primary Sources
2.3.2 Secondary Sources
2.4 Market Estimation
2.4.1 Bottom-Up Approach
2.4.2 Top-Down Approach
2.5 Forecasting Methodology
3 Executive Summary
4 Introduction
4.1 Overview
4.2 Key Industry Trends
5 Global G-Protein Coupled Receptors (GPCRs) Market
5.1 Market Overview
5.2 Market Performance
5.3 Impact of COVID-19
5.4 Market Forecast
6 Market Breakup by Product
6.1 Cell Lines
6.1.1 Market Trends
6.1.2 Market Forecast
6.2 Detection Kits
6.2.1 Market Trends
6.2.2 Market Forecast
6.3 Cell Culture Reagents
6.3.1 Market Trends
6.3.2 Market Forecast
6.4 Ligands
6.4.1 Market Trends
6.4.2 Market Forecast
7 Market Breakup by Assay Type
7.1 cAMP Functional Assays
7.1.1 Market Trends
7.1.2 Market Forecast
7.2 Calcium Functional Assays
7.2.1 Market Trends
7.2.2 Market Forecast
7.3 β-Arrestin Functional Assays
7.3.1 Market Trends
7.3.2 Market Forecast
7.4 Radioligand Binding and GTPγS Functional Assays
7.4.1 Market Trends
7.4.2 Market Forecast
7.5 Internalization Assays
7.5.1 Market Trends
7.5.2 Market Forecast
7.6 Trafficking Assays
7.6.1 Market Trends
7.6.2 Market Forecast
7.7 Others
7.7.1 Market Trends
7.7.2 Market Forecast
8 Market Breakup by Application
8.1 Cancer Research
8.1.1 Market Trends
8.1.2 Market Forecast
8.2 CNS Research
8.2.1 Market Trends
8.2.2 Market Forecast
8.3 Metabolic Research
8.3.1 Market Trends
8.3.2 Market Forecast
8.4 Cardiovascular Research
8.4.1 Market Trends
8.4.2 Market Forecast
8.5 Inflammation Research
8.5.1 Market Trends
8.5.2 Market Forecast
8.6 Respiratory Research
8.6.1 Market Trends
8.6.2 Market Forecast
8.7 Others
8.7.1 Market Trends
8.7.2 Market Forecast
9 Market Breakup by Region
9.1 North America
9.1.1 United States
9.1.1.1 Market Trends
9.1.1.2 Market Forecast
9.1.2 Canada
9.1.2.1 Market Trends
9.1.2.2 Market Forecast
9.2 Asia-Pacific
9.2.1 China
9.2.1.1 Market Trends
9.2.1.2 Market Forecast
9.2.2 Japan
9.2.2.1 Market Trends
9.2.2.2 Market Forecast
9.2.3 India
9.2.3.1 Market Trends
9.2.3.2 Market Forecast
9.2.4 South Korea
9.2.4.1 Market Trends
9.2.4.2 Market Forecast
9.2.5 Australia
9.2.5.1 Market Trends
9.2.5.2 Market Forecast
9.2.6 Indonesia
9.2.6.1 Market Trends
9.2.6.2 Market Forecast
9.2.7 Others
9.2.7.1 Market Trends
9.2.7.2 Market Forecast
9.3 Europe
9.3.1 Germany
9.3.1.1 Market Trends
9.3.1.2 Market Forecast
9.3.2 France
9.3.2.1 Market Trends
9.3.2.2 Market Forecast
9.3.3 United Kingdom
9.3.3.1 Market Trends
9.3.3.2 Market Forecast
9.3.4 Italy
9.3.4.1 Market Trends
9.3.4.2 Market Forecast
9.3.5 Spain
9.3.5.1 Market Trends
9.3.5.2 Market Forecast
9.3.6 Russia
9.3.6.1 Market Trends
9.3.6.2 Market Forecast
9.3.7 Others
9.3.7.1 Market Trends
9.3.7.2 Market Forecast
9.4 Latin America
9.4.1 Brazil
9.4.1.1 Market Trends
9.4.1.2 Market Forecast
9.4.2 Mexico
9.4.2.1 Market Trends
9.4.2.2 Market Forecast
9.4.3 Others
9.4.3.1 Market Trends
9.4.3.2 Market Forecast
9.5 Middle East and Africa
9.5.1 Market Trends
9.5.2 Market Breakup by Country
9.5.3 Market Forecast
10 Drivers, Restraints, and Opportunities
10.1 Overview
10.2 Drivers
10.3 Restraints
10.4 Opportunities
11 Value Chain Analysis
12 Porters Five Forces Analysis
12.1 Overview
12.2 Bargaining Power of Buyers
12.3 Bargaining Power of Suppliers
12.4 Degree of Competition
12.5 Threat of New Entrants
12.6 Threat of Substitutes
13 Price Analysis
14 Competitive Landscape
14.1 Market Structure
14.2 Key Players
14.3 Profiles of Key Players
14.3.1 Abcam plc
14.3.1.1 Company Overview
14.3.1.2 Product Portfolio
14.3.1.3 Financials
14.3.1.4 SWOT Analysis
14.3.2 Becton Dickinson and Company
14.3.2.1 Company Overview
14.3.2.2 Product Portfolio
14.3.2.3 Financials
14.3.2.4 SWOT Analysis
14.3.3 Enzo Biochem Inc.
14.3.3.1 Company Overview
14.3.3.2 Product Portfolio
14.3.3.3 Financials
14.3.3.4 SWOT Analysis
14.3.4 Eurofins DiscoverX Products LLC
14.3.4.1 Company Overview
14.3.4.2 Product Portfolio
14.3.4.3 Financials
14.3.4.4 SWOT Analysis
14.3.5 HD Biosciences Co. Ltd. (WuXi AppTec)
14.3.5.1 Company Overview
14.3.5.2 Product Portfolio
14.3.6 Merck KGaA
14.3.6.1 Company Overview
14.3.6.2 Product Portfolio
14.3.6.3 Financials
14.3.6.4 SWOT Analysis
14.3.7 Molecular Devices LLC (Danaher Corporation)
14.3.7.1 Company Overview
14.3.7.2 Product Portfolio
14.3.8 PerkinElmer Inc.
14.3.8.1 Company Overview
14.3.8.2 Product Portfolio
14.3.8.3 Financials
14.3.8.4 SWOT Analysis
14.3.9 Promega Corporation
14.3.9.1 Company Overview
14.3.9.2 Product Portfolio
14.3.10 Thermo Fisher Scientific Inc.
14.3.10.1 Company Overview
14.3.10.2 Product Portfolio
14.3.10.3 Financials
14.3.10.4 SWOT Analysis

List of Figures
Figure 1: Global: G-Protein Coupled Receptors Market: Major Drivers and Challenges
Figure 2: Global: G-Protein Coupled Receptors Market: Sales Value (in Billion US$), 2018-2023
Figure 3: Global: G-Protein Coupled Receptors Market Forecast: Sales Value (in Billion US$), 2024-2032
Figure 4: Global: G-Protein Coupled Receptors Market: Breakup by Product (in %), 2023
Figure 5: Global: G-Protein Coupled Receptors Market: Breakup by Assay Type (in %), 2023
Figure 6: Global: G-Protein Coupled Receptors Market: Breakup by Application (in %), 2023
Figure 7: Global: G-Protein Coupled Receptors Market: Breakup by Region (in %), 2023
Figure 8: Global: G-Protein Coupled Receptors (Cell Lines) Market: Sales Value (in Million US$), 2018 & 2023
Figure 9: Global: G-Protein Coupled Receptors (Cell Lines) Market Forecast: Sales Value (in Million US$), 2024-2032
Figure 10: Global: G-Protein Coupled Receptors (Detection Kits) Market: Sales Value (in Million US$), 2018 & 2023
Figure 11: Global: G-Protein Coupled Receptors (Detection Kits) Market Forecast: Sales Value (in Million US$), 2024-2032
Figure 12: Global: G-Protein Coupled Receptors (Cell Culture Reagents) Market: Sales Value (in Million US$), 2018 & 2023
Figure 13: Global: G-Protein Coupled Receptors (Cell Culture Reagents) Market Forecast: Sales Value (in Million US$), 2024-2032
Figure 14: Global: G-Protein Coupled Receptors (Ligands) Market: Sales Value (in Million US$), 2018 & 2023
Figure 15: Global: G-Protein Coupled Receptors (Ligands) Market Forecast: Sales Value (in Million US$), 2024-2032
Figure 16: Global: G-Protein Coupled Receptors (cAMP Functional Assays) Market: Sales Value (in Million US$), 2018 & 2023
Figure 17: Global: G-Protein Coupled Receptors (cAMP Functional Assays) Market Forecast: Sales Value (in Million US$), 2024-2032
Figure 18: Global: G-Protein Coupled Receptors (Calcium Functional Assays) Market: Sales Value (in Million US$), 2018 & 2023
Figure 19: Global: G-Protein Coupled Receptors (Calcium Functional Assays) Market Forecast: Sales Value (in Million US$), 2024-2032
Figure 20: Global: G-Protein Coupled Receptors (β-Arrestin Functional Assays) Market: Sales Value (in Million US$), 2018 & 2023
Figure 21: Global: G-Protein Coupled Receptors (β-Arrestin Functional Assays) Market Forecast: Sales Value (in Million US$), 2024-2032
Figure 22: Global: G-Protein Coupled Receptors (Radioligand Binding and GTPγS Functional Assays) Market: Sales Value (in Million US$), 2018 & 2023
Figure 23: Global: G-Protein Coupled Receptors (Radioligand Binding and GTPγS Functional Assays) Market Forecast: Sales Value (in Million US$), 2024-2032
Figure 24: Global: G-Protein Coupled Receptors (Internalization Assays) Market: Sales Value (in Million US$), 2018 & 2023
Figure 25: Global: G-Protein Coupled Receptors (Internalization Assays) Market Forecast: Sales Value (in Million US$), 2024-2032
Figure 26: Global: G-Protein Coupled Receptors (Trafficking Assays) Market: Sales Value (in Million US$), 2018 & 2023
Figure 27: Global: G-Protein Coupled Receptors (Trafficking Assays) Market Forecast: Sales Value (in Million US$), 2024-2032
Figure 28: Global: G-Protein Coupled Receptors (Other Assay Types) Market: Sales Value (in Million US$), 2018 & 2023
Figure 29: Global: G-Protein Coupled Receptors (Other Assay Types) Market Forecast: Sales Value (in Million US$), 2024-2032
Figure 30: Global: G-Protein Coupled Receptors (Cancer Research) Market: Sales Value (in Million US$), 2018 & 2023
Figure 31: Global: G-Protein Coupled Receptors (Cancer Research) Market Forecast: Sales Value (in Million US$), 2024-2032
Figure 32: Global: G-Protein Coupled Receptors (CNS Research) Market: Sales Value (in Million US$), 2018 & 2023
Figure 33: Global: G-Protein Coupled Receptors (CNS Research) Market Forecast: Sales Value (in Million US$), 2024-2032
Figure 34: Global: G-Protein Coupled Receptors (Metabolic Research) Market: Sales Value (in Million US$), 2018 & 2023
Figure 35: Global: G-Protein Coupled Receptors (Metabolic Research) Market Forecast: Sales Value (in Million US$), 2024-2032
Figure 36: Global: G-Protein Coupled Receptors (Cardiovascular Research) Market: Sales Value (in Million US$), 2018 & 2023
Figure 37: Global: G-Protein Coupled Receptors (Cardiovascular Research) Market Forecast: Sales Value (in Million US$), 2024-2032
Figure 38: Global: G-Protein Coupled Receptors (Inflammation Research) Market: Sales Value (in Million US$), 2018 & 2023
Figure 39: Global: G-Protein Coupled Receptors (Inflammation Research) Market Forecast: Sales Value (in Million US$), 2024-2032
Figure 40: Global: G-Protein Coupled Receptors (Respiratory Research) Market: Sales Value (in Million US$), 2018 & 2023
Figure 41: Global: G-Protein Coupled Receptors (Respiratory Research) Market Forecast: Sales Value (in Million US$), 2024-2032
Figure 42: Global: G-Protein Coupled Receptors (Other Applications) Market: Sales Value (in Million US$), 2018 & 2023
Figure 43: Global: G-Protein Coupled Receptors (Other Applications) Market Forecast: Sales Value (in Million US$), 2024-2032
Figure 44: North America: G-Protein Coupled Receptors Market: Sales Value (in Million US$), 2018 & 2023
Figure 45: North America: G-Protein Coupled Receptors Market Forecast: Sales Value (in Million US$), 2024-2032
Figure 46: United States: G-Protein Coupled Receptors Market: Sales Value (in Million US$), 2018 & 2023
Figure 47: United States: G-Protein Coupled Receptors Market Forecast: Sales Value (in Million US$), 2024-2032
Figure 48: Canada: G-Protein Coupled Receptors Market: Sales Value (in Million US$), 2018 & 2023
Figure 49: Canada: G-Protein Coupled Receptors Market Forecast: Sales Value (in Million US$), 2024-2032
Figure 50: Asia-Pacific: G-Protein Coupled Receptors Market: Sales Value (in Million US$), 2018 & 2023
Figure 51: Asia-Pacific: G-Protein Coupled Receptors Market Forecast: Sales Value (in Million US$), 2024-2032
Figure 52: China: G-Protein Coupled Receptors Market: Sales Value (in Million US$), 2018 & 2023
Figure 53: China: G-Protein Coupled Receptors Market Forecast: Sales Value (in Million US$), 2024-2032
Figure 54: Japan: G-Protein Coupled Receptors Market: Sales Value (in Million US$), 2018 & 2023
Figure 55: Japan: G-Protein Coupled Receptors Market Forecast: Sales Value (in Million US$), 2024-2032
Figure 56: India: G-Protein Coupled Receptors Market: Sales Value (in Million US$), 2018 & 2023
Figure 57: India: G-Protein Coupled Receptors Market Forecast: Sales Value (in Million US$), 2024-2032
Figure 58: South Korea: G-Protein Coupled Receptors Market: Sales Value (in Million US$), 2018 & 2023
Figure 59: South Korea: G-Protein Coupled Receptors Market Forecast: Sales Value (in Million US$), 2024-2032
Figure 60: Australia: G-Protein Coupled Receptors Market: Sales Value (in Million US$), 2018 & 2023
Figure 61: Australia: G-Protein Coupled Receptors Market Forecast: Sales Value (in Million US$), 2024-2032
Figure 62: Indonesia: G-Protein Coupled Receptors Market: Sales Value (in Million US$), 2018 & 2023
Figure 63: Indonesia: G-Protein Coupled Receptors Market Forecast: Sales Value (in Million US$), 2024-2032
Figure 64: Others: G-Protein Coupled Receptors Market: Sales Value (in Million US$), 2018 & 2023
Figure 65: Others: G-Protein Coupled Receptors Market Forecast: Sales Value (in Million US$), 2024-2032
Figure 66: Europe: G-Protein Coupled Receptors Market: Sales Value (in Million US$), 2018 & 2023
Figure 67: Europe: G-Protein Coupled Receptors Market Forecast: Sales Value (in Million US$), 2024-2032
Figure 68: Germany: G-Protein Coupled Receptors Market: Sales Value (in Million US$), 2018 & 2023
Figure 69: Germany: G-Protein Coupled Receptors Market Forecast: Sales Value (in Million US$), 2024-2032
Figure 70: France: G-Protein Coupled Receptors Market: Sales Value (in Million US$), 2018 & 2023
Figure 71: France: G-Protein Coupled Receptors Market Forecast: Sales Value (in Million US$), 2024-2032
Figure 72: United Kingdom: G-Protein Coupled Receptors Market: Sales Value (in Million US$), 2018 & 2023
Figure 73: United Kingdom: G-Protein Coupled Receptors Market Forecast: Sales Value (in Million US$), 2024-2032
Figure 74: Italy: G-Protein Coupled Receptors Market: Sales Value (in Million US$), 2018 & 2023
Figure 75: Italy: G-Protein Coupled Receptors Market Forecast: Sales Value (in Million US$), 2024-2032
Figure 76: Spain: G-Protein Coupled Receptors Market: Sales Value (in Million US$), 2018 & 2023
Figure 77: Spain: G-Protein Coupled Receptors Market Forecast: Sales Value (in Million US$), 2024-2032
Figure 78: Russia: G-Protein Coupled Receptors Market: Sales Value (in Million US$), 2018 & 2023
Figure 79: Russia: G-Protein Coupled Receptors Market Forecast: Sales Value (in Million US$), 2024-2032
Figure 80: Others: G-Protein Coupled Receptors Market: Sales Value (in Million US$), 2018 & 2023
Figure 81: Others: G-Protein Coupled Receptors Market Forecast: Sales Value (in Million US$), 2024-2032
Figure 82: Latin America: G-Protein Coupled Receptors Market: Sales Value (in Million US$), 2018 & 2023
Figure 83: Latin America: G-Protein Coupled Receptors Market Forecast: Sales Value (in Million US$), 2024-2032
Figure 84: Brazil: G-Protein Coupled Receptors Market: Sales Value (in Million US$), 2018 & 2023
Figure 85: Brazil: G-Protein Coupled Receptors Market Forecast: Sales Value (in Million US$), 2024-2032
Figure 86: Mexico: G-Protein Coupled Receptors Market: Sales Value (in Million US$), 2018 & 2023
Figure 87: Mexico: G-Protein Coupled Receptors Market Forecast: Sales Value (in Million US$), 2024-2032
Figure 88: Others: G-Protein Coupled Receptors Market: Sales Value (in Million US$), 2018 & 2023
Figure 89: Others: G-Protein Coupled Receptors Market Forecast: Sales Value (in Million US$), 2024-2032
Figure 90: Middle East and Africa: G-Protein Coupled Receptors Market: Sales Value (in Million US$), 2018 & 2023
Figure 91: Middle East and Africa: G-Protein Coupled Receptors Market: Breakup by Country (in %), 2023
Figure 92: Middle East and Africa: G-Protein Coupled Receptors Market Forecast: Sales Value (in Million US$), 2024-2032
Figure 93: Global: G-Protein Coupled Receptors Industry: Drivers, Restraints, and Opportunities
Figure 94: Global: G-Protein Coupled Receptors Industry: Value Chain Analysis
Figure 95: Global: G-Protein Coupled Receptors Industry: Porter's Five Forces Analysis
List of Tables
Table 1: Global: G-Protein Coupled Receptors Market: Key Industry Highlights, 2023 & 2032
Table 2: Global: G-Protein Coupled Receptors Market Forecast: Breakup by Product (in Million US$), 2024-2032
Table 3: Global: G-Protein Coupled Receptors Market Forecast: Breakup by Assay Type (in Million US$), 2024-2032
Table 4: Global: G-Protein Coupled Receptors Market Forecast: Breakup by Application (in Million US$), 2024-2032
Table 5: Global: G-Protein Coupled Receptors Market Forecast: Breakup by Region (in Million US$), 2024-2032
Table 6: Global: G-Protein Coupled Receptors Market: Competitive Structure
Table 7: Global: G-Protein Coupled Receptors Market: Key Players