Summary

Glutathione Market Size, Demand Insights
Glutathione market size was worth US$ YY million in 2021 and is estimated to reach US$ YY million by 2029, growing at a CAGR of 7.0 % during the forecast period (2023-2030).
Glutathione is present as an antioxidant in plants, animals, fungi, bacteria, and archaea. Glutathione can protect vital cellular components from damage. It is a protein made up of three amino acids sold as a dietary supplement. Glutathione is an important antioxidant involved in DNA synthesis, immunity, and sperm formation, among other things.
Glutathione is a tripeptide found in most mammalian tissues that consist of the three amino acids cysteine, glutamic acid, and glycine. Glutathione serves as an antioxidant, free radical scavenger, and detoxifying agent. In addition, glutathione plays a crucial role in the formation of leukotrienes, the uptake of amino acids, and as a cofactor for the enzyme glutathione peroxidase. This substance interacts with various dangerous chemical species, including halides, epoxides, and free radicals, as a platform for glutathione S-transferase to produce safe, inactive products. By reducing methemoglobin and peroxides, these processes guard erythrocytes against oxidative damage. Glutathione is the most important antioxidant found in cells. It performs various other functions, including xenobiotic detoxification and much more. Glutathione's main benefits include antioxidant support, detoxification, immune support, skin brightening, and sports nutrition. Glutathione protects cells from oxidative stress and aids in the body's detoxification process. The increased demand for supplements is increasing the body's storage of glutathione. Glutathione also aids in achieving strength training results by sustaining the increase in nitric oxide production following exercise. Glutathione aids in fatigue reduction and recovery. For example, glutathione from Setria Glutathione and L-Citrulline manufacturers is used in sports nutrition.
Glutathione Market Dynamics and Trends
The antioxidant function is the primary driver of the global Glutathione market. Both glutathiones oxidized and glutathione-reduced components are high in antioxidants. The growth driver is detoxification, which has increased glutathione demand and is expected to increase market size over the forecast period. Because of the numerous applications, glutathione-based cosmetics are also gaining traction in the market. Moreover, rising raw material prices are expected to limit the market growth.
Increasing demand for glutathione in pharmaceutical and other industries
Glutathione is increasingly used in various industries, including food and beverage, cosmetics, and pharmaceuticals. The antioxidant function is the primary factor driving the global glutathione market. Antioxidants are abundant in both reduced and oxidized states. Diabetes, obesity, and skin-related diseases are rapidly becoming prevalent in the area, accounting for many consumer-related diseases, owing primarily to a lack of sufficient diet, a shift in dietary patterns, and a hectic daily schedule. As people better understand health issues, greater vitamin demand will increase glutathione's market share.
Another primary function is detoxification, which has increased glutathione demand and is expected to increase sales over the forecast period. Because of the numerous end-use applications, glutathione-based cosmetics are also gaining traction in the market. For example, glutathione soaps have several advantages, including the fact that the ingredient aids in the restoration of age, the removal of uneven skin color & pigmentation issues, and the promotion of brighter & healthier skin.
Rising demand for skin care products
The oxidized glutathione segment accounted for a sizable portion of global glutathione demand. One of the major drivers for glutathione is increased consumer spending on skincare and cosmetic products, affected by higher disposable incomes, rising living standards, and a growing population of working women. Oxidized glutathione is found in various skin care products, including anti-aging creams, lotions, and moisturizers. These products help prevent the formation of wrinkles, increase the moisture content of the stratum corneum and improve skin smoothness.
Furthermore, the cosmetic industry has been growing rapidly in recent years and is expected to grow quickly during the forecast period. Due to the substance's widespread use in personal care and cosmetic items such as sun cream and lotion, the glutathione market may benefit from the growing cosmetic industry in the coming years.
The high price of raw materials and stringent regulations
Reduced glutathione or oxidized glutathione are important raw materials in producing glutathione resins. Raw materials and processing dominate the cost structure of the glutathione resin manufacturing process. Raw materials contribute to a large portion of the cost structure in producing glutathione resins, closely followed by processing costs, which account for a significant portion. A major factor influencing the market is the high cost of raw materials and the high cost of processing. As a result, manufacturers invest in R&D to find a cost-effective alternative.
Stringent regulations imposed by regulatory authorities in various regions on production, labeling, and product usage are expected to limit glutathione market growth to some extent over the projection period. For example, the FDA corresponded with L-glutathione makers to confirm that the ingredient is not proposed in sterile pharmaceuticals, even though L-glutathione is solely promoted in the U.S. for use in dietary supplements. However, manufacturers warn their U.S. clients about using L-glutathione in sterile medications to remain competitive.
COVID-19 Impact on Glutathione Market Growth
The pandemic moderately impacted the glutathione market in 2020, owing to supply-demand constraints in key economies worldwide. Furthermore, it impacted several end-use industries, which influenced overall market growth. However, due to the stability of these industries, key end-use applications such as pharmaceutical, biotechnology, and others are expected to drive product demand. Glutathione is crucial in enhancing the immune system and aiding in the fight against numerous toxins found in the environment. This trait promotes glutathione market demand in the COVID-19 pandemic, which is expected to expand in the next years.
Glutathione Market Segment and Shares Analysis
By type, the glutathione market is segmented into glutathione oxidized and glutathione reduced.
Rising cancer cases globally propel the demand for glutathione reduced.
Cancer is one of the leading global causes of death and its prevalence is steadily increasing. According to the World Health Organization, cancer was responsible for 9.6 million deaths in 2020. Population growth, lifestyle changes, increased smokers and tobacco use contributes to rising cancer prevalence. As a result of its ability to prevent the harmful side effects of chemotherapy in cancer patients, the rising cancer burden worldwide should drive the demand for reduced glutathione.
The rising demand for therapeutic antibodies for patient treatment is a major driver of the pharmaceutical industry's expansion. A shift toward replacing traditional separation techniques, such as distillation and filtration, with chromatography has also fueled innovation in chromatography applications in various new markets.
Glutathione Market Geographical Analysis
Presence of a large no. of pharmaceutical players in North America
Because several pharmaceutical manufacturers, including Johnson and Pfizer & Johnson, have a high demand for drug manufacturing in the region. As a result, the region's large presence of pharmaceutical manufacturers creates a huge opportunity for the glutathione market, as the product is widely used to produce many pharmaceutical products.
The product's benefits, such as tissue repair and building and immune system boosting, are attributed to the product's growth. The product also treats various diseases such as asthma, cataracts, and anemia. Other significant drivers of the regional market include rising demand for biochemical research applications and vaccine development to combat diseases such as the ongoing Coronavirus pandemic. The increasing use of purified proteins and antibodies in therapeutic areas is expected to drive product demand in North America.
The U.S. is the largest market for chromatography resin in North America, accounting for the largest market share. Government initiatives over the last few years, like funding to improve the productivity of affinity chromatography beads such as magnetic and agarose beads, have benefited the U.S. economy, resulting in increased economic competitiveness and technological capability.
Glutathione Companies and Competitive Landscape
Players collaborate and partner with other operators to expand into the untapped market. In addition, companies are forming joint ventures with players in emerging markets, investing in new manufacturing units, and conducting research and development to establish a strong footprint and portfolio in the global market.
KOHJIN Life Sciences conducted a study on the benefits of Glutathione for Lipid Metabolism and Sports Nutrition in 2015. The studies show that taking GSH orally increased Mitochondrial DNA and AMP levels and PGC-1 activated-kinase expression in skeletal muscle. Furthermore, according to the findings, glutathione improves lipid metabolism and acidification in muscles during exercise.
Key players in the global glutathione market include Kyowa Hakko Bio Co., Ltd., Shandong Jincheng Biological Pharmaceutical Co., Ltd., KOHJIN Life Sciences Co., Ltd., Anhui GSH Biotechnology Co., Ltd, Kaiping Genuine Biochemical Pharmaceutical Co. Ltd., Herbo Nutra, Haihang Industry Co., Ltd., Meteoric Biopharmaceuticals Pvt. Ltd., Xi’an Fengzu Biological Technology Co., Ltd. and Cayman Chemical Company.
Kyowa Hakko Bio Co., Ltd.
Overview: Kyowa Hakko U.S.A., Inc. is the North and South American branch of KYOWA HAKKO BIO CO., LTD., a multinational ingredients manufacturer whose major mission is to deliver health solutions that encourage optimal health and quality of life. Kyowa's components meet the most stringent quality assurance standards in the nutritional supplement, health food, cosmetic and pharmaceutical industries in the U.S., as pioneers in developing and implementing patented fermentation technology. Kyowa Hakko U.S.A. represents a comprehensive line of quality-assured, ultra-pure amino acids and related substances and well-researched, branded products.
Product Portfolio: Setria Glutathione is available from the company. It is a highly absorbable tripeptide produced by a fermentation process that can assist in replenishing the body's stores that may have been depleted by bad food, pharmaceutical medicines, or even the natural aging process. Country Life Lung Defense, Healthy Origins, Zaca, Intox-Detox, and Nature's Answer Brocco Glutathione are just a few supplement companies that carry Setria. Setria Glutathione is allergen-free and vegetarian. It has no additives, artificial flavors, or preservatives and is produced using a revolutionary fermentation process that results in great purity and quality.
Key Development: Kyowa Hakko Bio Co. Ltd. expanded its global reach in 2019 by introducing a new product, Setria glutathione, in Indonesia. The company is dedicated to creating science-backed products that promote wellness and disease treatment. The product is a patented, allergen-free, clinically studied glutathione form that aids in increasing antioxidants in the human body. Kyowa Hakko launched its new "Breathe" brand campaign in 2021, highlighting Setria Glutathione, a proprietary glutathione component that promotes respiratory and immunological health.

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