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3D細胞培養：テクノロジーと世界市場3D Cell Cultures: Technologies and Global Markets レポートの範囲 本レポートは、世界の3D細胞培養技術市場を包括的に調査することを目的としています。本レポートでは、さまざまな種類の医療相互運用性ソリューションとその現在および過去の市場収益について... もっと見る
サマリーレポートの範囲本レポートは、世界の3D細胞培養技術市場を包括的に調査することを目的としています。本レポートでは、さまざまな種類の医療相互運用性ソリューションとその現在および過去の市場収益について詳細に説明しています。 本レポートの対象範囲は、産業界、学術研究者、政府研究所、独立研究グループによって使用されている主要な3D細胞培養の種類を網羅している。これには、細胞株、培地、血清、試薬、ソフトウェア、装置などの主な投入物が含まれる。市場の現状を分析し、将来の市場促進要因を検討し、今後5年間の成長予測を提示しています。 今回の改訂では、市場構造を再編成した。また、さまざまな製品分野のベースケースデータについて、より多くの調査を行った。3D細胞培養に使用される様々な製品に重点が置かれているが、アプリケーションの種類、エンドユーザー、地域といった観点からも市場を調査している。 レポートは以下を含む： - 17のデータ表と105の追加表 - 3D細胞培養技術に関連する世界市場概況 - 2020-2022年の過去の収益データ、2023年の推定値、2028年の予測を含む世界市場動向の詳細分析。この分析には、2028年までの年間平均成長率（CAGR）の予測も含まれています。 - 種類別、エンドユーザー別、地域別に分類した包括的な市場シェア分析を伴う、3D細胞培養技術に特化した現在の市場規模と収益成長見込みの評価 - 組織・細胞培養、セロミクス、ヒトがんモデル（HCMI）で使用される分析システムに関する情報 - 間葉系幹細胞のアッセイ開発、不定愁訴物質の体外試験、アッセイおよびアッセイキットに関する詳細情報 - がんやその他の疾患研究のための主なモデルクラス、がん研究における3Dモデルの利点、3D人工スキャフォールドの解説 - 市場のダイナミクス、特に成長促進要因、阻害要因、機会の分析、COVID-19が細胞培養の世界に与える影響についての考察 - バイオプリント製品の米国規制状況についての洞察；生物製剤、再生医療、異種移植の規制に関する基本ガイダンス - 最近の活動や主要特許のリストを含む関連特許分析 - Abcam PLC、Agilent Technologies Inc.、Corning Inc.、Merck KGAA、Beckman Coulter、Synvivo Inc.など、主要な市場参入企業の詳細なプロフィールを掲載。 目次Table of ContentsChapter 1 Introduction Study Goals and Objectives Reasons for Doing the Study Scope of Report What's New in This Report? Methodology and Information Sources Geographic Breakdown Segment Breakdown Chapter 2 Summary and Highlights Market Outlook Market Summary Chapter 3 Market Overview An Opening Comment on an Amazing Industry Industry Issues In Vitro versus In Vivo Dimensionality The Research Chain for 2D and 3D Cell Culture Best Practices Standardization Regulation Genomics Forcing the Hand of the FDA Leachables and Extractables Broad Issues Research Talent Shortages The Shifting International Picture Pace and Diversification of Innovation A Comment on the "Other" Areas of Cell Culture Omics Everywhere Is 2020 a Watershed Year for the Cell Culture Industry? Preliminary Market Analysis Cell Culture Market Growth Rate Estimates Assessing Large-Scale Media Consumption Needs Modeling Future Growth in Biopharmaceuticals Base Case for the Cell Culture Market Challenges in Projecting Sales and Growth Cell Culture Media Market Estimates Cell and Gene Therapy Bioprocessing Segment Evaluating Media Consumption for Biosimilars What About CDMOs? Microfluidics Bioreactors Internal Cell Culture Resources Is There Too Much Concentration of Ownership in Biotechnology? Characterizing Innovation in 3D Cell Culture Bioprinting Strategic Roadmap Chapter 4 Market, by Type Where Did Tissue and Cell Culture Start? History and Early Applications Invention of Tissue Culture Development of Sustained Cell Lines First Cell Culture Flask and Rigorous Techniques Lindbergh: The Cell Culture Equipment Pioneer Establishing Continuous Cell Lines Key Developments in Equipment Terminology and Concepts Tissue and Cell Culture Industry Tissue Culture and Cell Culture Definitions Cell Lines Care and Growth of Cell Culture Systems Media, Sera, and Reagents Gels and Scaffolds Microplates/Microtiter Plates Bioanalytical Instruments Bioanalytical Imaging Bioprinting Bioreactors Other Equipment for Cell Culture Adherent Approaches Traditional Roller Bottles Other Systems Information Technology: Software and Services for the Cell Culture Research Market Software for the Research Market in Cell Culture Software-Related Support Services Bioprocessing Consumables for Cell Culture Microcarriers for Large-Scale 3D Culture Sera for Large-Scale 3D Culture Media for Large-Scale 3D Culture Bioreactor Bags for Large-Scale 3D Culture Other Bioprocessing Equipment Analytical Equipment for Bioprocessing Automation Systems for Bioprocessing Support Equipment for Bioprocessing Aspects of Large-Scale Manufacturing of Biopharmaceuticals and Vaccines Suspension Proteins and Monoclonal Antibodies Adherent-Cell-Based Therapies and Vaccines Small-Scale Adherent to Make Somatic Cells, Stem Cells and Tissues Vaccines Vaccine Development as a Catalyst Vaccines Developed Using Human Cell Strains Exosome Manufacturing Viral Vector Manufacturing Lentivirus Manufacturing Plasmid Manufacturing Cell Culture End Users Pharma/Biopharma Universities Government CROs/CDMOS Other Cell Culture Applications Drug Discovery Clinical Development Toxicology Basic Research Bioprocessing Development Other Regional Markets The Americas Europe Asia-Pacific Rest of the World Chapter 5 Assays, Imaging and Analysis Assays Assay Development for Mesenchymal Stem Cells In Vitro Testing of Adventitious Agents Assays and Assay Kits Cell-Based Assays: Overview and Newer Developments Cells Used in Cell-Based Assays Notes on 3D Cell-Based Assays Kinetic Metabolism Assays Cell Proliferation Viability and Cytotoxicity Permeability Assays for Cell Viability and Survival Cell Invasion Cell Signaling and Communication Cytostatic Cell Death Assays Imaging Technology Imaging Assays Fluorescence as a Driver of Screening Analytical Systems Used in Tissue and Cell Culture Understanding "Cellomics" HCS Support of 3D Cell Culture NGS Discovery Pools Multiplex Assays Predictive Toxicology Neuro Safety The Omics Invasion Transcriptomics Chapter 6 Regulation and Standardization U.S. Regulatory Status of Bioprinted Products Basic Guidance for the Regulation of Biologics Guidance for Regenerative Medicine Guidance for Xenotransplants Guidance for Regenerative Medicine: Emergency Approval Regulating Bioprinted Products Chapter 7 3D Models for Cancer Disease Modeling Cancer Main Classes of Models for Researching Cancer and Other Diseases Cell Lines Spheroids and Organoids Genetically Engineered Mouse Model (GEMM) Patient-Derived Tumor Xenografts (PDXs) Overview: Cancer at the Cellular Level In Vivo (Animal) Testing Standard Empire of the Mouse Humanized Mice 2D Culture 3D Requirements Cell Number and Viability Migration and Invasion Unmet Needs: Angiogenesis and Immune System Evasion Benefits of 3D Models to Cancer Research Greater Distinction in Cell Morphology and Proliferation Greater Gene Expression and Cell Behavior Better Models of Cell Migration and Invasion Cell Heterogeneity Breast Cancer as a Driver of 3D Cultures Structure, Polarity and Apoptosis Melanoma as a Driver of 3D Cultures Moving to Spheroid Configurations 3D Systems in Cancer Research Multicellular Tumor Spheroids Multilayered Cell Cultures 3D Engineered Scaffolds Natural Materials Synthetic Materials Human Cancer Model Initiative (HCMI) Next-Generation Human Cancer Models Drug Sensitivity and Resistance Altered Signaling and Sensitivity Drug Resistance Cellular Signaling Cellular Signaling Mediated by Integrins Drug Screening Approaches and Endpoints Spheroid Applications Metastasis via 3D Cell Migration Model Metastasis via Lung-on-Chip Cancer Metabolism Future Horizons Metastases Co-culture Vascularization Cancer-Associated Fibroblasts Cancer Stem Cells Combination Therapies Biologics Development Tumor Recurrence Patient-Derived Cells Patient-Derived Tumor Xenografts (PDXs) Evolution of PDX Platforms Chapter 8 Landscape for Toxicology and Drug Safety Testing Introduction Liver Toxicology Background Testing for Adverse Effects on the Skin New Assessment Methodologies Impact on 3D Cell Culture Toxicology Testing in Cosmetics Updated Regulatory Requirements Efficacy of Cosmetics and Cosmeceuticals Aspects of Cosmetic Toxicity Testing Skin Irritation Skin Corrosion Phototoxicity Skin Sensitization Eye Irritation Acute Systemic Toxicity Acute Toxicity Testing Cytotoxicity Assays for Acute Toxicity Testing Chronic and Repeated Dose Toxicity Carcinogenicity and Genotoxicity Overview In Vitro Methods: Background and Recent Developments Regulatory versus Drug Development Applications Efforts to Reduce False Positives Recent Innovations in Screening Future Challenge: Non-genotoxic Carcinogens Reproductive and Developmental Toxicity Background Following the Reproductive Cycle Development and Reproductive Tox Testing Types Zebrafish Model for Developmental Toxicity Screening Combination of Zebrafish and Stem Cells Biomedical Frontiers: Male Testis Endocrine Disruptor Screening Background Environmental Toxicology Impacts In Vitro Methods ToxCast and Tox 21 Initiatives Future Challenge: Thyroid Disruption BG1 Assay Toxicokinetics and ADME In Vitro Developments Metabolism Pharmacokinetics of Low-Turnover Compounds Organotypic Models 3D Models for Skin 3D Corneal System Absorption Barrier Models Gastrointestinal Lung Blood-Brain Barrier Real Architecture for 3D Tissue Barriers and Extracellular Matrix Liver Toxicity Uniqueness and Complexity of Liver Liver as a Key Driver for 3D Innovation In Vitro Liver Applications In Vivo Liver Function and Structure Liver Metabolism In Vitro Liver Models Co-cultures of Hepatocytes and Macrophages 3D Liver Models Bioprinted Liver Tissue Detected Hepatosphere Structures and Functionality Ideal Criteria Drug Resistance Transporter Studies Achieving Heterotypic Cell-Cell Contacts Unmet Needs and Future Drivers of Innovation Morphogen Signaling Multi-donor Liver Cells Kidney Toxicity Applications Future Challenge: Stem-Cell Derived Kidney Cells Bioprinted Kidney Tissue Pancreatic Toxicology Applications Cardiovascular Toxicity Commercial Avenue Collaboration with Regulators Cardiovascular Drug Discovery Microelectrode Arrays (MEAs) Based on Impedance Surrogate for Aortic Ring Assay via Bioprinted Magnetics Vasodilator Activity 3D Engineered Heart Tissues Chapter 9 Market Breakdown by Region Introduction North America United States Canada Europe Germany United Kingdom Asia-Pacific China Japan India South Korea Singapore Rest of the World Chapter 10 Stem Cell Landscape A History of Stem Cells Major and Minor Research Areas for Stem Cells 3D Stem Cell Culture Systems Plate or Culture Dish Spinner Flask and Rotating Wall Vessel Perfusion Bioreactor and Microcarrier Systems Shortcomings Microfluidics and Stem Cells Short Review of Stem Cell Biology Embryogenesis Growth, Structure and Morphology of Stem Cells Stem Cell Differentiation Stem Cell Differentiation versus Proliferation Extracellular Matrix and Stem Cells Soluble Factors Manufacturing Stem Cells Controlling Embryoid Body Formation Forced Aggregation Cultures Hanging-Drop Approach Applications Stem Cell Markers for High-Throughput Screening Teratomas and the Teratoma Assay Fujifilm (Cellular Dynamics Inc.) Stem Cell Research Breakthroughs Stem Cells for Neuroscience Discovery and Development Example: Alzheimer's Research Background: B-Amyloid Cascade Hypothesis Human iPSC-Derived Models New 3D Model Other Advantages of 3D Envisioned Applications Other 3D Neuro Applications Stem Cells for Cardiovascular Discovery Stem Cells for the Development of Regenerative Medicine Background: Allogenic versus Autologous MicroRNAs Induced Pluripotent Stem Cells (IPS) Chapter 11 Regenerative Medicine: Organ Transplants and Skin Substitutes Regenerative Medicine Need for Organ Transplants Applications in Regenerative Medicine Investments in Regenerative Medicine Skin Substitutes Industry Tissue Culture Allograft and Autograft Products Tissue Engineering in Regenerative Medicine Chapter 12 Company Profiles 3D BIOPRINTING SOLUTIONS 3D BIOTEK LLC 4D TECHNOLOGY CORP. ABCAM PLC AKRON BIOTECH AGILENT TECHNOLOGIES INC. ALPCO AMSBIO BECKMAN COULTER INC. BIOINSPIRED SOLUTIONS BIOTIME INC. BIOVISION INC. CELL APPLICATIONS INC. CELLINK CORNING INC. CYPROTEX CYTIVA CYTOO SA EMD MILLIPORE / MERCK KGAA EMULATE INC. ENVISIONTEC INC. EPITHELIX EUROFINS SAS GREINER BIO-ONE INTERNATIONAL GMBH HAMILTON ROBOTICS HUB ORGANOIDS HUREL CORP. INSPHERO INVITROCUE KIYATEC INC. LIFENET HEALTH LOREM VASCULAR / CYTORI THERAPEUTICS INC. MATTEK MIMETAS INC. ORGANOVO HOLDINGS INC. PERKINELMER INC. PLASTICELL LTD. PLURISTEM THERAPEUTICS INC. POIETIS PROMEGA CORP. SEAHORSE BIOSCIENCE STEMCELL TECHNOLOGIES STRATATECH CORP. SYNVIVO INC. TAP BIOSYSTEMS TECAN TRADING AG ZEN-BIO INC.
SummaryReport Scope: Table of ContentsTable of ContentsChapter 1 Introduction Study Goals and Objectives Reasons for Doing the Study Scope of Report What's New in This Report? Methodology and Information Sources Geographic Breakdown Segment Breakdown Chapter 2 Summary and Highlights Market Outlook Market Summary Chapter 3 Market Overview An Opening Comment on an Amazing Industry Industry Issues In Vitro versus In Vivo Dimensionality The Research Chain for 2D and 3D Cell Culture Best Practices Standardization Regulation Genomics Forcing the Hand of the FDA Leachables and Extractables Broad Issues Research Talent Shortages The Shifting International Picture Pace and Diversification of Innovation A Comment on the "Other" Areas of Cell Culture Omics Everywhere Is 2020 a Watershed Year for the Cell Culture Industry? Preliminary Market Analysis Cell Culture Market Growth Rate Estimates Assessing Large-Scale Media Consumption Needs Modeling Future Growth in Biopharmaceuticals Base Case for the Cell Culture Market Challenges in Projecting Sales and Growth Cell Culture Media Market Estimates Cell and Gene Therapy Bioprocessing Segment Evaluating Media Consumption for Biosimilars What About CDMOs? Microfluidics Bioreactors Internal Cell Culture Resources Is There Too Much Concentration of Ownership in Biotechnology? Characterizing Innovation in 3D Cell Culture Bioprinting Strategic Roadmap Chapter 4 Market, by Type Where Did Tissue and Cell Culture Start? History and Early Applications Invention of Tissue Culture Development of Sustained Cell Lines First Cell Culture Flask and Rigorous Techniques Lindbergh: The Cell Culture Equipment Pioneer Establishing Continuous Cell Lines Key Developments in Equipment Terminology and Concepts Tissue and Cell Culture Industry Tissue Culture and Cell Culture Definitions Cell Lines Care and Growth of Cell Culture Systems Media, Sera, and Reagents Gels and Scaffolds Microplates/Microtiter Plates Bioanalytical Instruments Bioanalytical Imaging Bioprinting Bioreactors Other Equipment for Cell Culture Adherent Approaches Traditional Roller Bottles Other Systems Information Technology: Software and Services for the Cell Culture Research Market Software for the Research Market in Cell Culture Software-Related Support Services Bioprocessing Consumables for Cell Culture Microcarriers for Large-Scale 3D Culture Sera for Large-Scale 3D Culture Media for Large-Scale 3D Culture Bioreactor Bags for Large-Scale 3D Culture Other Bioprocessing Equipment Analytical Equipment for Bioprocessing Automation Systems for Bioprocessing Support Equipment for Bioprocessing Aspects of Large-Scale Manufacturing of Biopharmaceuticals and Vaccines Suspension Proteins and Monoclonal Antibodies Adherent-Cell-Based Therapies and Vaccines Small-Scale Adherent to Make Somatic Cells, Stem Cells and Tissues Vaccines Vaccine Development as a Catalyst Vaccines Developed Using Human Cell Strains Exosome Manufacturing Viral Vector Manufacturing Lentivirus Manufacturing Plasmid Manufacturing Cell Culture End Users Pharma/Biopharma Universities Government CROs/CDMOS Other Cell Culture Applications Drug Discovery Clinical Development Toxicology Basic Research Bioprocessing Development Other Regional Markets The Americas Europe Asia-Pacific Rest of the World Chapter 5 Assays, Imaging and Analysis Assays Assay Development for Mesenchymal Stem Cells In Vitro Testing of Adventitious Agents Assays and Assay Kits Cell-Based Assays: Overview and Newer Developments Cells Used in Cell-Based Assays Notes on 3D Cell-Based Assays Kinetic Metabolism Assays Cell Proliferation Viability and Cytotoxicity Permeability Assays for Cell Viability and Survival Cell Invasion Cell Signaling and Communication Cytostatic Cell Death Assays Imaging Technology Imaging Assays Fluorescence as a Driver of Screening Analytical Systems Used in Tissue and Cell Culture Understanding "Cellomics" HCS Support of 3D Cell Culture NGS Discovery Pools Multiplex Assays Predictive Toxicology Neuro Safety The Omics Invasion Transcriptomics Chapter 6 Regulation and Standardization U.S. Regulatory Status of Bioprinted Products Basic Guidance for the Regulation of Biologics Guidance for Regenerative Medicine Guidance for Xenotransplants Guidance for Regenerative Medicine: Emergency Approval Regulating Bioprinted Products Chapter 7 3D Models for Cancer Disease Modeling Cancer Main Classes of Models for Researching Cancer and Other Diseases Cell Lines Spheroids and Organoids Genetically Engineered Mouse Model (GEMM) Patient-Derived Tumor Xenografts (PDXs) Overview: Cancer at the Cellular Level In Vivo (Animal) Testing Standard Empire of the Mouse Humanized Mice 2D Culture 3D Requirements Cell Number and Viability Migration and Invasion Unmet Needs: Angiogenesis and Immune System Evasion Benefits of 3D Models to Cancer Research Greater Distinction in Cell Morphology and Proliferation Greater Gene Expression and Cell Behavior Better Models of Cell Migration and Invasion Cell Heterogeneity Breast Cancer as a Driver of 3D Cultures Structure, Polarity and Apoptosis Melanoma as a Driver of 3D Cultures Moving to Spheroid Configurations 3D Systems in Cancer Research Multicellular Tumor Spheroids Multilayered Cell Cultures 3D Engineered Scaffolds Natural Materials Synthetic Materials Human Cancer Model Initiative (HCMI) Next-Generation Human Cancer Models Drug Sensitivity and Resistance Altered Signaling and Sensitivity Drug Resistance Cellular Signaling Cellular Signaling Mediated by Integrins Drug Screening Approaches and Endpoints Spheroid Applications Metastasis via 3D Cell Migration Model Metastasis via Lung-on-Chip Cancer Metabolism Future Horizons Metastases Co-culture Vascularization Cancer-Associated Fibroblasts Cancer Stem Cells Combination Therapies Biologics Development Tumor Recurrence Patient-Derived Cells Patient-Derived Tumor Xenografts (PDXs) Evolution of PDX Platforms Chapter 8 Landscape for Toxicology and Drug Safety Testing Introduction Liver Toxicology Background Testing for Adverse Effects on the Skin New Assessment Methodologies Impact on 3D Cell Culture Toxicology Testing in Cosmetics Updated Regulatory Requirements Efficacy of Cosmetics and Cosmeceuticals Aspects of Cosmetic Toxicity Testing Skin Irritation Skin Corrosion Phototoxicity Skin Sensitization Eye Irritation Acute Systemic Toxicity Acute Toxicity Testing Cytotoxicity Assays for Acute Toxicity Testing Chronic and Repeated Dose Toxicity Carcinogenicity and Genotoxicity Overview In Vitro Methods: Background and Recent Developments Regulatory versus Drug Development Applications Efforts to Reduce False Positives Recent Innovations in Screening Future Challenge: Non-genotoxic Carcinogens Reproductive and Developmental Toxicity Background Following the Reproductive Cycle Development and Reproductive Tox Testing Types Zebrafish Model for Developmental Toxicity Screening Combination of Zebrafish and Stem Cells Biomedical Frontiers: Male Testis Endocrine Disruptor Screening Background Environmental Toxicology Impacts In Vitro Methods ToxCast and Tox 21 Initiatives Future Challenge: Thyroid Disruption BG1 Assay Toxicokinetics and ADME In Vitro Developments Metabolism Pharmacokinetics of Low-Turnover Compounds Organotypic Models 3D Models for Skin 3D Corneal System Absorption Barrier Models Gastrointestinal Lung Blood-Brain Barrier Real Architecture for 3D Tissue Barriers and Extracellular Matrix Liver Toxicity Uniqueness and Complexity of Liver Liver as a Key Driver for 3D Innovation In Vitro Liver Applications In Vivo Liver Function and Structure Liver Metabolism In Vitro Liver Models Co-cultures of Hepatocytes and Macrophages 3D Liver Models Bioprinted Liver Tissue Detected Hepatosphere Structures and Functionality Ideal Criteria Drug Resistance Transporter Studies Achieving Heterotypic Cell-Cell Contacts Unmet Needs and Future Drivers of Innovation Morphogen Signaling Multi-donor Liver Cells Kidney Toxicity Applications Future Challenge: Stem-Cell Derived Kidney Cells Bioprinted Kidney Tissue Pancreatic Toxicology Applications Cardiovascular Toxicity Commercial Avenue Collaboration with Regulators Cardiovascular Drug Discovery Microelectrode Arrays (MEAs) Based on Impedance Surrogate for Aortic Ring Assay via Bioprinted Magnetics Vasodilator Activity 3D Engineered Heart Tissues Chapter 9 Market Breakdown by Region Introduction North America United States Canada Europe Germany United Kingdom Asia-Pacific China Japan India South Korea Singapore Rest of the World Chapter 10 Stem Cell Landscape A History of Stem Cells Major and Minor Research Areas for Stem Cells 3D Stem Cell Culture Systems Plate or Culture Dish Spinner Flask and Rotating Wall Vessel Perfusion Bioreactor and Microcarrier Systems Shortcomings Microfluidics and Stem Cells Short Review of Stem Cell Biology Embryogenesis Growth, Structure and Morphology of Stem Cells Stem Cell Differentiation Stem Cell Differentiation versus Proliferation Extracellular Matrix and Stem Cells Soluble Factors Manufacturing Stem Cells Controlling Embryoid Body Formation Forced Aggregation Cultures Hanging-Drop Approach Applications Stem Cell Markers for High-Throughput Screening Teratomas and the Teratoma Assay Fujifilm (Cellular Dynamics Inc.) Stem Cell Research Breakthroughs Stem Cells for Neuroscience Discovery and Development Example: Alzheimer's Research Background: B-Amyloid Cascade Hypothesis Human iPSC-Derived Models New 3D Model Other Advantages of 3D Envisioned Applications Other 3D Neuro Applications Stem Cells for Cardiovascular Discovery Stem Cells for the Development of Regenerative Medicine Background: Allogenic versus Autologous MicroRNAs Induced Pluripotent Stem Cells (IPS) Chapter 11 Regenerative Medicine: Organ Transplants and Skin Substitutes Regenerative Medicine Need for Organ Transplants Applications in Regenerative Medicine Investments in Regenerative Medicine Skin Substitutes Industry Tissue Culture Allograft and Autograft Products Tissue Engineering in Regenerative Medicine Chapter 12 Company Profiles 3D BIOPRINTING SOLUTIONS 3D BIOTEK LLC 4D TECHNOLOGY CORP. ABCAM PLC AKRON BIOTECH AGILENT TECHNOLOGIES INC. ALPCO AMSBIO BECKMAN COULTER INC. BIOINSPIRED SOLUTIONS BIOTIME INC. BIOVISION INC. CELL APPLICATIONS INC. CELLINK CORNING INC. CYPROTEX CYTIVA CYTOO SA EMD MILLIPORE / MERCK KGAA EMULATE INC. ENVISIONTEC INC. EPITHELIX EUROFINS SAS GREINER BIO-ONE INTERNATIONAL GMBH HAMILTON ROBOTICS HUB ORGANOIDS HUREL CORP. INSPHERO INVITROCUE KIYATEC INC. LIFENET HEALTH LOREM VASCULAR / CYTORI THERAPEUTICS INC. MATTEK MIMETAS INC. ORGANOVO HOLDINGS INC. PERKINELMER INC. PLASTICELL LTD. PLURISTEM THERAPEUTICS INC. POIETIS PROMEGA CORP. SEAHORSE BIOSCIENCE STEMCELL TECHNOLOGIES STRATATECH CORP. SYNVIVO INC. TAP BIOSYSTEMS TECAN TRADING AG ZEN-BIO INC.
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