Summary

Global Bone Grafts And Substitutes Market was valued at USD 3.45 Billion in 2024 and is expected to reach USD 5.15 Billion by 2030 with a CAGR of 6.86% during the forecast period. The Global Bone Grafts and Substitutes Market is driven by several key factors, including the rising incidence of bone-related disorders, an aging population, and increasing demand for minimally invasive surgeries. The growing prevalence of conditions like osteoarthritis, osteoporosis, and bone fractures, particularly among the elderly, has spurred the demand for effective bone repair solutions. Advancements in biotechnology and materials science have led to the development of more efficient, biocompatible bone grafts and substitutes, such as synthetic and allograft options. The increasing focus on orthopedic and spinal surgeries, coupled with a shift towards less invasive procedures, is also contributing to market growth. Enhanced healthcare infrastructure and rising awareness of bone health globally are further accelerating market expansion.
Key Market Drivers
Rising Incidence of Bone-Related Disorders and Trauma
The Global Bone Grafts and Substitutes Market is experiencing significant growth due to the increasing prevalence of bone-related disorders and trauma. Conditions like osteoporosis, osteoarthritis, bone infections, and degenerative bone diseases are on the rise, particularly among the aging population. Osteoporosis, in particular, is a major health concern, as it leads to a weakening of bones and an increased risk of fractures. This disease is widespread among older adults, especially women after menopause. Osteoarthritis, which involves the degeneration of joint cartilage and the underlying bone, is becoming more prevalent due to longer life expectancies. These diseases often require bone grafts for joint replacement surgeries, spinal fusion, and other orthopedic procedures. According to WHO, around 1.71 billion people globally suffer from musculoskeletal conditions, making them the primary cause of disability worldwide. Low back pain, in particular, is the leading cause of disability in 160 countries. These conditions severely restrict mobility and dexterity, often resulting in early retirement, diminished well-being, and a reduced ability to engage fully in society.
The incidence of traumatic bone injuries, such as fractures caused by accidents or sports injuries, is another driver. As trauma and bone-related diseases increase, so does the demand for bone grafts and substitutes that aid in healing, promoting bone regeneration, and repairing fractures or defects. The requirement for advanced solutions like autografts, allografts, and synthetic bone substitutes is critical for addressing these growing medical needs, ensuring that the market continues to expand in response to these health concerns.
Aging Global Population
The global aging population is one of the most prominent drivers of the Bone Grafts and Substitutes Market. As life expectancy continues to rise, especially in developed nations, the proportion of elderly individuals is growing, leading to an increased prevalence of age-related bone disorders. These individuals are more prone to conditions such as osteoporosis, bone fractures, and degenerative joint diseases, which significantly impact bone health. The elderly often suffer from weakened bones, making them more susceptible to fractures from falls or minimal impact. As a result, orthopedic procedures such as hip, knee, and spinal surgeries are increasingly required to treat fractures and improve mobility. Bone grafts and substitutes play a crucial role in these surgeries, as they help to facilitate the healing process, promote bone growth, and prevent complications. The demand for bone grafts in spinal fusion surgeries for age-related conditions such as degenerative disc disease has been growing. The need for these products is expected to rise steadily as the aging population continues to grow globally, especially in regions like North America, Europe, and parts of Asia-Pacific. This demographic shift is a primary driver, contributing to the overall market expansion.
Advancements in Technology and Materials Science
Advances in technology and materials science have had a profound impact on the Bone Grafts and Substitutes Market, fostering growth by providing innovative solutions that offer improved outcomes. In February 2022, Orthofix Medical Inc. introduced Opus BA, a synthetic bioactive bone graft solution specifically developed for lumbar and cervical spine fusion surgeries.
New materials used in bone grafts and substitutes have dramatically enhanced their performance, making them more effective and versatile. For example, synthetic bone substitutes made from materials such as calcium phosphate, hydroxyapatite, and bioactive glass offer excellent osteoconductivity, which supports the growth of new bone tissue. In addition, the development of bioactive scaffolds that promote cellular activity, such as mesenchymal stem cells (MSCs), is improving the biological healing process and accelerating recovery times. Advancements in 3D printing technologies have also allowed for the creation of customized bone grafts tailored to fit the patient’s specific anatomy, improving surgical precision and healing rates. Innovations like collagen-based grafts and nanotechnology-enabled products are enhancing the biocompatibility and integration of grafts with the host bone. These technological improvements are driving market demand, as patients and healthcare providers seek the most advanced and effective solutions for bone regeneration and healing. As research continues and new materials are developed, the range of available bone grafts and substitutes will expand, attracting more patients and healthcare professionals to adopt these advanced technologies.
Increasing Awareness and Demand for Minimally Invasive Procedures
As patients increasingly seek less invasive treatment options, the demand for minimally invasive procedures in orthopedic surgeries, including those involving bone grafts and substitutes, is rising. Minimally invasive techniques, which reduce the need for large incisions and result in faster recovery times, are becoming the preferred choice in many cases. Bone grafts, particularly synthetic and allografts, are increasingly used in these types of procedures due to their ease of application and effectiveness. In June 2024, comprehensive scientific research was published detailing the advanced features of Biogennix's TrelCor bone graft material. Biogennix, a company specializing in osteobiologics for bone transplant surgeries, developed TrelCor as a novel dual-phase bone graft. Its surface is composed of nanocrystalline hydroxycarbanoapatite (HCA), a material specifically designed to enhance bone growth.
With advancements in surgical techniques and improved bone graft materials, these procedures can be performed with smaller incisions, less risk of infection, and quicker recovery periods. This growing preference for minimally invasive surgery has led to an increased demand for bone grafts and substitutes that are compatible with these techniques. As healthcare providers continue to adopt new technologies aimed at reducing surgical trauma and improving patient outcomes, the popularity of minimally invasive orthopedic procedures is expected to continue to rise, thereby increasing the demand for bone grafts and substitutes. Patients benefit from these procedures through faster recovery, reduced complications, and shorter hospital stays, making this approach more attractive for both patients and surgeons.
Key Market Challenges
High Cost of Bone Grafts and Substitutes
One of the significant challenges facing the Global Bone Grafts and Substitutes Market is the high cost of bone grafts, especially for advanced options like autografts, allografts, and synthetic materials. While autografts are considered the gold standard in bone grafting due to their biocompatibility, they involve high costs related to both the harvesting process and surgical procedures. Allografts, which are derived from human donors, also come with significant processing, storage, and handling costs. Synthetic bone graft substitutes, though increasingly popular, can be expensive to manufacture and distribute, impacting their affordability for patients in lower-income regions. The high cost of these products often limits their accessibility, particularly in emerging markets or in countries without adequate insurance coverage for orthopedic surgeries. This pricing challenge could inhibit market growth, as patients may opt for less effective or less expensive alternatives. Healthcare systems in developing countries may struggle to afford and adopt these advanced technologies, leading to disparities in treatment access.
Risk of Complications and Rejection
Despite the advancements in bone grafting technologies, there is still the potential for complications associated with the use of bone grafts and substitutes. For example, autografts, which involve using the patient's own bone tissue, carry the risk of infection, pain, and the potential for donor site morbidity, as the area from which the bone is harvested can suffer its own complications. Allografts, while reducing the risk of donor site morbidity, carry the risk of immune rejection and disease transmission, despite extensive screening and processing. Synthetic bone graft substitutes, although they avoid the issues of rejection or infection, may not integrate as effectively with the surrounding bone tissue, leading to delayed healing, non-union of fractures, or implant failure. These risks, though rare, can undermine patient confidence in these treatments and may result in the need for additional surgeries, which could hinder market growth. Efforts to improve the biocompatibility of bone graft substitutes and minimize complications are ongoing, but these challenges remain an important factor to consider.
Key Market Trends
Increasing Healthcare Access in Developing Countries
The growing availability and improvement of healthcare infrastructure in emerging economies are contributing to the growth of the Bone Grafts and Substitutes Market. As countries in regions such as Asia-Pacific, South America, and the Middle East continue to develop their healthcare systems, access to advanced treatments like bone grafts is becoming more widespread. In these regions, increasing disposable income, urbanization, and government investment in healthcare infrastructure are allowing more people to seek medical attention for bone-related issues. In July 2024, Paradigm BioDevices, Inc. will introduce VisiCORE, an innovative bone graft harvesting device designed for foot and ankle fusion procedures. Featuring a transparent collecting tube and exclusive Graft Retention Technology (GRT)™, VisiCORE minimizes bone graft loss during collection, reduces the number of passes needed to obtain an adequate graft, and lowers donor site complications. Additionally, the system allows real-time viewing of bone graft harvests.
The rise in healthcare awareness and the availability of advanced medical technologies have enabled healthcare providers in these regions to adopt modern surgical techniques that require the use of bone grafts and substitutes. As more hospitals and clinics in developing countries gain access to these technologies, the demand for effective bone regeneration products is likely to increase. This is particularly true in countries like India, China, Brazil, and several Middle Eastern nations, where the prevalence of trauma-related injuries and bone diseases is rising due to lifestyle changes, industrialization, and aging populations. The market for bone grafts and substitutes is expanding as the reach of these products extends beyond developed regions into the emerging economies, further driving global growth.
Rising Sports Injuries and Trauma Cases
The increasing number of sports injuries, especially in contact sports, is contributing significantly to the Global Bone Grafts and Substitutes Market. Athletes, particularly those involved in high-impact sports such as football, rugby, basketball, and soccer, are at a higher risk of bone fractures, joint injuries, and ligament damage. In addition to sports injuries, the rise in traffic accidents and other trauma-related cases is also leading to an increased need for bone repair solutions. Bone grafts and substitutes are essential in treating complex fractures, particularly those involving large bone defects, where natural healing may not be sufficient. The demand for these products is not only driven by the need to repair bones following trauma but also to facilitate the restoration of full function in patients, especially athletes who require rapid recovery to return to their sport. As trauma-related injuries continue to rise globally, both in sports and everyday life, the need for effective bone grafting and substitution techniques will increase, fueling market growth. Advances in regenerative medicine and faster recovery times are making bone grafts a more attractive option for trauma patients, further expanding the market’s potential.
Increased Focus on Regenerative Medicine and Stem Cell Therapy
The growing focus on regenerative medicine and stem cell therapies has also contributed to the expansion of the Bone Grafts and Substitutes Market. Regenerative medicine aims to restore the function of damaged tissues and organs through various techniques, including the use of stem cells and biological scaffolds. In bone regeneration, stem cells, often derived from the patient’s own body, can be combined with bone grafts and substitutes to accelerate the healing process and promote the growth of new bone tissue. Stem cell-based therapies and growth factors are increasingly being integrated with traditional bone graft substitutes to enhance the overall effectiveness of treatment. These innovations allow for a more biologically active environment at the site of injury or surgery, improving healing outcomes and reducing complications. As the field of regenerative medicine continues to evolve and gain acceptance, the combination of stem cell therapies with bone graft substitutes is expected to become more common, creating new growth opportunities in the market. The ability to not only repair but also regenerate bone tissue through advanced biological therapies positions the market for continued growth, attracting investment and attention from both medical professionals and patients alike.
Segmental Insights
Material Type Insights
Allografts was the fastest-growing segment in the global Bone Grafts and Substitutes Market, driven by their proven efficacy, versatility, and widespread use in treating various bone injuries and conditions. Sourced from human cadaveric donors, allografts are processed and sterilized for medical use, playing a crucial role in procedures like spinal fusions, joint reconstructions, and trauma surgeries. Their rapid growth is fueled by key factors that make them a preferred choice for both patients and healthcare providers.
Highly effective in orthopedic surgeries, allografts are especially useful for treating large bone defects or fractures, as they integrate well with surrounding tissue and support natural bone healing. They are essential in spinal fusion surgeries, offering structural support while stimulating bone regeneration. With a low rejection rate compared to other graft materials, the risk of disease transmission is minimized through rigorous screening and processing.
Another key advantage of allografts is their availability and biological compatibility. As human-derived tissue, they naturally integrate into the patient’s skeletal system, promoting faster healing and reducing complications such as implant failure or graft rejection. Their biological composition activates osteoblasts and supports bone remodeling, improving overall patient outcomes..
Application Insights
Based on the Application segment, spinal fusion surgeries continue to dominate the global Bone Grafts and Substitutes Market. Spinal fusion is a critical surgical procedure used to treat a variety of spinal disorders, including degenerative disc disease, scoliosis, and fractures. It involves fusing two or more vertebrae in the spine to eliminate motion between them and provide stability, often requiring the use of bone grafts to facilitate the healing process and stimulate bone growth. The dominance of spinal fusion in the bone grafts market can be attributed to several key factors, including the high prevalence of spinal conditions, the increasing demand for advanced surgical treatments, and the critical role that bone grafts play in the success of spinal fusion surgeries.
One of the main reasons spinal fusion procedures are driving the growth of the Bone Grafts and Substitutes Market is the rising incidence of spinal disorders. Spinal conditions, such as degenerative disc disease, herniated discs, and spinal deformities, are becoming increasingly common due to factors like aging populations, sedentary lifestyles, poor posture, and high rates of obesity. According to global health statistics, spinal disorders affect a significant portion of the population, with lower back pain being one of the leading causes of disability worldwide. As the number of patients with spinal issues continues to grow, so does the demand for effective treatments such as spinal fusion surgery. This increasing patient pool translates into a greater need for bone grafts and substitutes to support the healing process and ensure successful fusion outcomes.
Regional Insights
North America was dominating the global Bone Grafts and Substitutes Market. This region, particularly the United States and Canada, has seen significant growth in the demand for bone graft products due to a combination of factors, including an aging population, advanced healthcare infrastructure, high healthcare spending, and the presence of leading medical device companies. North America’s dominance in the bone grafts market is a result of its robust healthcare system, widespread access to cutting-edge medical technologies, and strong emphasis on advanced orthopedic treatments.
A key driver of North America's dominance is the aging population. As the population in the United States and Canada continues to age, the incidence of musculoskeletal disorders such as osteoporosis, degenerative disc disease, and bone fractures has significantly increased. These conditions often require surgical interventions like spinal fusion, joint reconstruction, and bone trauma surgeries, where bone grafts and substitutes are critical. The older population is more prone to bone-related issues, leading to a greater demand for bone grafts that are needed to facilitate healing, promote bone regeneration, and support complex surgeries. The aging demographic, coupled with an increased focus on maintaining a higher quality of life, has contributed to the continued growth of the bone grafts market in North America.
Advanced healthcare infrastructure in North America provides patients with access to some of the most cutting-edge treatments and technologies available in the medical field. The United States, in particular, is home to world-renowned hospitals, specialized orthopedic clinics, and research institutions that use the latest advancements in bone grafting materials and techniques. These institutions are constantly developing and adopting new bone graft substitutes, such as synthetic bone grafts, stem cell-based therapies, and bioactive materials, which contribute to the region's dominant position in the global market. In addition, the availability of highly skilled surgeons who are proficient in using these advanced materials and performing intricate procedures has also played a crucial role in maintaining North America’s leadership in the bone grafts and substitutes sector.
Key Market Players
• Medical Device Business Services, Inc.
• Baxter International Inc.
• NuVasive, Inc.
• Smith & Nephew plc
• Medtronic plc
• Orthofix Medical Inc.
• OST Laboratories
• Zimmer Biomet Holdings, Inc.
• Geistlich Pharma India, Inc.
• Stryker Corporation
Report Scope:
In this report, the Global Bone Grafts And Substitutes Market has been segmented into the following categories, in addition to the industry trends which have also been detailed below:
• Bone Grafts And Substitutes Market, By Material Type:
o Allograft
o Synthetic
o Composites
o Polymers
o Bone Morphogenic Proteins
• Bone Grafts And Substitutes Market, By Application:
o Craniomaxillofacial
o Dental
o Foot & Ankle
o Joint Reconstruction
o Long Bone
o Spinal Fusion
• Bone Grafts And Substitutes Market, By Region:
o North America
§ United States
§ Canada
§ Mexico
o Europe
§ France
§ United Kingdom
§ Italy
§ Germany
§ Spain
o Asia-Pacific
§ China
§ India
§ Japan
§ Australia
§ South Korea
o South America
§ Brazil
§ Argentina
§ Colombia
o Middle East & Africa
§ South Africa
§ Saudi Arabia
§ UAE
Competitive Landscape
Company Profiles: Detailed analysis of the major companies present in the Global Bone Grafts And Substitutes Market.
Available Customizations:
Global Bone Grafts And Substitutes market report with the given market data, TechSci Research offers customizations according to a company's specific needs. The following customization options are available for the report:
Company Information
• Detailed analysis and profiling of additional market players (up to five).

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Table of Contents

1. Product Overview
1.1. Market Definition
1.2. Scope of the Market
1.2.1. Markets Covered
1.2.2. Years Considered for Study
1.2.3. Key Market Segmentations
2. Research Methodology
2.1. Objective of the Study
2.2. Baseline Methodology
2.3. Key Industry Partners
2.4. Major Association and Secondary Sources
2.5. Forecasting Methodology
2.6. Data Triangulation & Validations
2.7. Assumptions and Limitations
3. Executive Summary
3.1. Overview of the Market
3.2. Overview of Key Market Segmentations
3.3. Overview of Key Market Players
3.4. Overview of Key Regions/Countries
3.5. Overview of Market Drivers, Challenges, Trends
4. Voice of Customer
5. Global Bone Grafts and Substitutes Market Outlook
5.1. Market Size & Forecast
5.1.1. By Value
5.2. Market Share & Forecast
5.2.1. By Material Type (Allograft, Synthetic, Composites, Polymers, and Bone Morphogenic Proteins)
5.2.2. By Application (Craniomaxillofacial, Dental, Foot & Ankle, Joint Reconstruction, Long Bone, and Spinal Fusion)
5.2.3. By Region
5.2.4. By Company (2024)
5.3. Market Map
6. North America Bone Grafts and Substitutes Market Outlook
6.1. Market Size & Forecast
6.1.1. By Value
6.2. Market Share & Forecast
6.2.1. By Material Type
6.2.2. By Application
6.2.3. By Country
6.3. North America: Country Analysis
6.3.1. United States Bone Grafts and Substitutes Market Outlook
6.3.1.1. Market Size & Forecast
6.3.1.1.1. By Value
6.3.1.2. Market Share & Forecast
6.3.1.2.1. By Material Type
6.3.1.2.2. By Application
6.3.2. Canada Bone Grafts and Substitutes Market Outlook
6.3.2.1. Market Size & Forecast
6.3.2.1.1. By Value
6.3.2.2. Market Share & Forecast
6.3.2.2.1. By Material Type
6.3.2.2.2. By Application
6.3.3. Mexico Bone Grafts and Substitutes Market Outlook
6.3.3.1. Market Size & Forecast
6.3.3.1.1. By Value
6.3.3.2. Market Share & Forecast
6.3.3.2.1. By Material Type
6.3.3.2.2. By Application
7. Europe Bone Grafts and Substitutes Market Outlook
7.1. Market Size & Forecast
7.1.1. By Value
7.2. Market Share & Forecast
7.2.1. By Material Type
7.2.2. By Application
7.2.3. By Country
7.3. Europe: Country Analysis
7.3.1. Germany Bone Grafts and Substitutes Market Outlook
7.3.1.1. Market Size & Forecast
7.3.1.1.1. By Value
7.3.1.2. Market Share & Forecast
7.3.1.2.1. By Material Type
7.3.1.2.2. By Application
7.3.2. United Kingdom Bone Grafts and Substitutes Market Outlook
7.3.2.1. Market Size & Forecast
7.3.2.1.1. By Value
7.3.2.2. Market Share & Forecast
7.3.2.2.1. By Material Type
7.3.2.2.2. By Application
7.3.3. Italy Bone Grafts and Substitutes Market Outlook
7.3.3.1. Market Size & Forecast
7.3.3.1.1. By Value
7.3.3.2. Market Share & Forecast
7.3.3.2.1. By Material Type
7.3.3.2.2. By Application
7.3.4. France Bone Grafts and Substitutes Market Outlook
7.3.4.1. Market Size & Forecast
7.3.4.1.1. By Value
7.3.4.2. Market Share & Forecast
7.3.4.2.1. By Material Type
7.3.4.2.2. By Application
7.3.5. Spain Bone Grafts and Substitutes Market Outlook
7.3.5.1. Market Size & Forecast
7.3.5.1.1. By Value
7.3.5.2. Market Share & Forecast
7.3.5.2.1. By Material Type
7.3.5.2.2. By Application
8. Asia-Pacific Bone Grafts and Substitutes Market Outlook
8.1. Market Size & Forecast
8.1.1. By Value
8.2. Market Share & Forecast
8.2.1. By Material Type
8.2.2. By Application
8.2.3. By Country
8.3. Asia-Pacific: Country Analysis
8.3.1. China Bone Grafts and Substitutes Market Outlook
8.3.1.1. Market Size & Forecast
8.3.1.1.1. By Value
8.3.1.2. Market Share & Forecast
8.3.1.2.1. By Material Type
8.3.1.2.2. By Application
8.3.2. India Bone Grafts and Substitutes Market Outlook
8.3.2.1. Market Size & Forecast
8.3.2.1.1. By Value
8.3.2.2. Market Share & Forecast
8.3.2.2.1. By Material Type
8.3.2.2.2. By Application
8.3.3. Japan Bone Grafts and Substitutes Market Outlook
8.3.3.1. Market Size & Forecast
8.3.3.1.1. By Value
8.3.3.2. Market Share & Forecast
8.3.3.2.1. By Material Type
8.3.3.2.2. By Application
8.3.4. South Korea Bone Grafts and Substitutes Market Outlook
8.3.4.1. Market Size & Forecast
8.3.4.1.1. By Value
8.3.4.2. Market Share & Forecast
8.3.4.2.1. By Material Type
8.3.4.2.2. By Application
8.3.5. Australia Bone Grafts and Substitutes Market Outlook
8.3.5.1. Market Size & Forecast
8.3.5.1.1. By Value
8.3.5.2. Market Share & Forecast
8.3.5.2.1. By Material Type
8.3.5.2.2. By Application
9. South America Bone Grafts and Substitutes Market Outlook
9.1. Market Size & Forecast
9.1.1. By Value
9.2. Market Share & Forecast
9.2.1. By Material Type
9.2.2. By Application
9.2.3. By Country
9.3. South America: Country Analysis
9.3.1. Brazil Bone Grafts and Substitutes Market Outlook
9.3.1.1. Market Size & Forecast
9.3.1.1.1. By Value
9.3.1.2. Market Share & Forecast
9.3.1.2.1. By Material Type
9.3.1.2.2. By Application
9.3.2. Argentina Bone Grafts and Substitutes Market Outlook
9.3.2.1. Market Size & Forecast
9.3.2.1.1. By Value
9.3.2.2. Market Share & Forecast
9.3.2.2.1. By Material Type
9.3.2.2.2. By Application
9.3.3. Colombia Bone Grafts and Substitutes Market Outlook
9.3.3.1. Market Size & Forecast
9.3.3.1.1. By Value
9.3.3.2. Market Share & Forecast
9.3.3.2.1. By Material Type
9.3.3.2.2. By Application
10. Middle East and Africa Bone Grafts and Substitutes Market Outlook
10.1. Market Size & Forecast
10.1.1. By Value
10.2. Market Share & Forecast
10.2.1. By Material Type
10.2.2. By Application
10.2.3. By Country
10.3. MEA: Country Analysis
10.3.1. South Africa Bone Grafts and Substitutes Market Outlook
10.3.1.1. Market Size & Forecast
10.3.1.1.1. By Value
10.3.1.2. Market Share & Forecast
10.3.1.2.1. By Material Type
10.3.1.2.2. By Application
10.3.2. Saudi Arabia Bone Grafts and Substitutes Market Outlook
10.3.2.1. Market Size & Forecast
10.3.2.1.1. By Value
10.3.2.2. Market Share & Forecast
10.3.2.2.1. By Material Type
10.3.2.2.2. By Application
10.3.3. UAE Bone Grafts and Substitutes Market Outlook
10.3.3.1. Market Size & Forecast
10.3.3.1.1. By Value
10.3.3.2. Market Share & Forecast
10.3.3.2.1. By Material Type
10.3.3.2.2. By Application
11. Market Dynamics
11.1. Drivers
11.2. Challenges
12. Market Trends & Developments
12.1. Merger & Acquisition (If Any)
12.2. Product Launches (If Any)
12.3. Recent Developments
13. Porter’s Five Forces Analysis
13.1. Competition in the Industry
13.2. Potential of New Entrants
13.3. Power of Suppliers
13.4. Power of Customers
13.5. Threat of Substitute Products
14. Competitive Landscape
14.1. Medical Device Business Services, Inc.
14.1.1. Business Overview
14.1.2. Company Snapshot
14.1.3. Products & Services
14.1.4. Financials (As Reported)
14.1.5. Recent Developments
14.1.6. Key Personnel Details
14.1.7. SWOT Analysis
14.2. Baxter International Inc.
14.3. NuVasive, Inc.
14.4. Smith & Nephew plc
14.5. Medtronic plc
14.6. Orthofix Medical Inc.
14.7. OST Laboratories
14.8. Zimmer Biomet Holdings, Inc.
14.9. Geistlich Pharma India, Inc.
14.10. Stryker Corporation
15. Strategic Recommendations
16. About Us & Disclaimer